504376 RS 102895 hydrochloride - CAS 300815-41-2 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1ʹ-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4ʹ-piperidin]-2(1H)-one hydrochloride, RS 102895, RS102895

Primary Target: CCR2
504376
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
—
Request Pricing
—
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₂₁F₃N₂O₂•HCl 300815-41-2

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.04376.0001
      Retrieving availability...
      —
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          		 Glass bottle 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          —
          Request Pricing
          		 —
          Description
          OverviewA selective antagonist for CCR2 receptors (IC50 = 0.36 and 17.8 µM for CCR2b and CCR1 receptors, respectively). Blocks monocyte chemoattractant protein-1 induced calcium influx and chemotaxis (IC50 = 32 nM and 1.7 µM respectively). A potential anti-inflammatory therapeutic agent by Inhibiting α1A, α1D and 5-HT1A receptors.
          Catalogue Number504376
          Brand Family Calbiochem®
          Synonyms1ʹ-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4ʹ-piperidin]-2(1H)-one hydrochloride, RS 102895, RS102895
          References
          ReferencesLee, Y., 2010. Magnetic Resonance in Medicine. 64, 72.
          Clark, R.D., et al. 1983. J. Med. Chem. 26, 657.
          Mirzadegan, T., et al. 2000. J. Biol. Chem. 275, 5562.
          Mitchell, L., et al. 2012. Int. Immunopharmacol. 15, 357.
          Product Information
          CAS number300815-41-2
          FormOff-white powder
          Hill FormulaC₂₁H₂₁F₃N₂O₂•HCl
          Chemical formulaC₂₁H₂₁F₃N₂O₂•HCl
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetCCR2
          Primary Target IC<sub>50</sub>0.36 and 17.8 µM for human recombinant CCR2b and CCR1 receptors, respectively.
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +15°C to +30°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Lee, Y., 2010. Magnetic Resonance in Medicine. 64, 72.
          Clark, R.D., et al. 1983. J. Med. Chem. 26, 657.
          Mirzadegan, T., et al. 2000. J. Biol. Chem. 275, 5562.
          Mitchell, L., et al. 2012. Int. Immunopharmacol. 15, 357.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-June-2013 JSW
          Synonyms1ʹ-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4ʹ-piperidin]-2(1H)-one hydrochloride, RS 102895, RS102895
          DescriptionA selective antagonist for CCR2 receptors (IC50 = 0.36 and 17.8 µM for CCR2b and CCR1 receptors, respectively). Blocks monocyte chemoattractant protein-1 induced calcium influx and chemotaxis (IC50 = 32 nM and 1.7 µM respectively). A potential anti-inflammatory therapeutic agent by Inhibiting α1A, α1D and 5-HT1A receptors.
          FormOff-white powder
          CAS number300815-41-2
          Chemical formulaC₂₁H₂₁F₃N₂O₂•HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +15°C to +30°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLee, Y., 2010. Magnetic Resonance in Medicine. 64, 72.
          Clark, R.D., et al. 1983. J. Med. Chem. 26, 657.
          Mirzadegan, T., et al. 2000. J. Biol. Chem. 275, 5562.
          Mitchell, L., et al. 2012. Int. Immunopharmacol. 15, 357.