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553525 RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₂H₁₇N₃O 1290541-46-6

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553525-25MG
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      Glass bottle 25 mg
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      Description
      OverviewA cell-permeable pyridinylvinyl-quinazolinone compound that is shown to specifically inhibit human RAD51 (IC50 = 27.4 µM). Does not affect RecA even at much higher concentration (~250 µM). Directly interacts with RAD51 (Kd = 5.6 µM), and disrupts its binding to DNA and nucleoprotein filament formation. Blocks double-strand break-induced homologous recombination and enhances sensitivity of cells to Cisplatin (Cat. No. 232120) and Mitomycin C (Cat. No. 47589), (Cat. No. 475820). Diminishes co-aggregate formation between RAD51-ssDNA filament and dsDNA. RAD51-Stimulatory Compound-1, RS-1 (Cat. No. 553510) is also available.
      Catalogue Number553525
      Brand Family Calbiochem®
      Synonyms(E)-3-Benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one
      References
      ReferencesHuang, F., et al. 2012. J. Med. Chem. 55, 3031.
      Huang, F., et al. 2011. ACS Chem. Biol. 6, 628.
      Product Information
      CAS number1290541-46-6
      FormLight yellow powder
      Hill FormulaC₂₂H₁₇N₃O
      Chemical formulaC₂₂H₁₇N₃O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      553525

      References

      Reference overview
      Huang, F., et al. 2012. J. Med. Chem. 55, 3031.
      Huang, F., et al. 2011. ACS Chem. Biol. 6, 628.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-September-2013 JSW
      Synonyms(E)-3-Benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one
      DescriptionA cell-permeable pyridinylvinyl-quinazolinone compound that is shown to specifically inhibit human RAD51 (IC50 = 27.4 µM). Does not affect RecA even at much higher concentration (~250 µM). Directly interacts with RAD51 (Kd = 5.6 µM), and disrupts its binding to DNA and nucleoprotein filament formation. Blocks double-strand break-induced homologous recombination and enhances sensitivity of cells to Cisplatin (Cat. No. 232120) and Mitomycin C (Cat. No. 47589), (Cat. No. 475820). Diminishes co-aggregate formation between RAD51-ssDNA filament and dsDNA. RAD51-Stimulatory Compound-1, RS-1 (Cat. No. 553510) is also available.
      FormLight yellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1290541-46-6
      Chemical formulaC₂₂H₁₇N₃O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesHuang, F., et al. 2012. J. Med. Chem. 55, 3031.
      Huang, F., et al. 2011. ACS Chem. Biol. 6, 628.