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508514 Psalmotoxin-1 - Calbiochem

508514
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₀₀H₃₁₂N₆₂O₅₇S₆

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      Glass bottle 20 μg
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      Description
      OverviewA potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC50 = 0.9 nm) isolated from the Trinidad chevron tarantula. Psalmotoxin-1 (PcTx1) can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b. Binding site is blocked when dimerization with ASIC2a or ASIC3.
      Catalogue Number508514
      Brand Family Calbiochem®
      SynonymsASIC1a Inhibitor, Psalmotoxin 1
      References
      ReferencesQadri, Y. J. et al. 2009. J. Biol. Chem. 284, 17625.
      M. Mazzuca, et al. 2007. Nat Neurosci. 10, 943.
      Escoubas, P. et al. 2000. J. Biol. Chem. 275, 25116.
      Product Information
      FormColorless semi-solid to viscous liquid
      Hill Formula C₂₀₀H₃₁₂N₆₂O₅₇S₆
      Chemical formulaC₂₀₀H₃₁₂N₆₂O₅₇S₆
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetASIC1a
      Primary Target IC<sub>50</sub>0.9 nM
      Purity≥94% by HPLC
      Physicochemical Information
      Peptide SequenceEDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (disulfide bond 3-18, 10-23, 17-33)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Psalmotoxin-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Qadri, Y. J. et al. 2009. J. Biol. Chem. 284, 17625.
      M. Mazzuca, et al. 2007. Nat Neurosci. 10, 943.
      Escoubas, P. et al. 2000. J. Biol. Chem. 275, 25116.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-March-2019 JSW
      SynonymsASIC1a Inhibitor, Psalmotoxin 1
      DescriptionA potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC50 = 0.9 nm) isolated from the Trinidad chevron tarantula. Psalmotoxin-1 (PcTx1) can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b. Binding site is blocked when dimerization with ASIC2a or ASIC3.
      FormColorless semi-solid to viscous liquid
      Chemical formulaC₂₀₀H₃₁₂N₆₂O₅₇S₆
      Peptide SequenceEDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (disulfide bond 3-18, 10-23, 17-33)
      Purity≥94% by HPLC
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesQadri, Y. J. et al. 2009. J. Biol. Chem. 284, 17625.
      M. Mazzuca, et al. 2007. Nat Neurosci. 10, 943.
      Escoubas, P. et al. 2000. J. Biol. Chem. 275, 25116.