539211 Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₉H₆Br₄O₅Na₂ • 3H₂O 17372-87-1

Pricing & Availability

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539211-50MG
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      Plastic ampoule 50 mg
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      Description
      OverviewA xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 and 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 and Suv39H2).
      Catalogue Number539211
      Brand Family Calbiochem®
      SynonymsDisodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III
      References
      ReferencesCheng, D., et al. 2004. J. Biol. Chem. 279, 23892.
      Product Information
      CAS number17372-87-1
      FormReddish brown solid
      Hill FormulaC₂₉H₆Br₄O₅Na₂ • 3H₂O
      Chemical formulaC₂₉H₆Br₄O₅Na₂ • 3H₂O
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90%
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 24/25-36/37/39-45

      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      539211

      References

      Reference overview
      Cheng, D., et al. 2004. J. Biol. Chem. 279, 23892.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-May-2009 RFH
      SynonymsDisodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III
      DescriptionA xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 & 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 & Suv39H2).
      FormReddish brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number17372-87-1
      Chemical formulaC₂₉H₆Br₄O₅Na₂ • 3H₂O
      Structure formulaStructure formula
      Purity≥90%
      SolubilityH₂O (50 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesCheng, D., et al. 2004. J. Biol. Chem. 279, 23892.