539175 Proteasome Inhibitor IV - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₃₀H₃₈N₄O₆

Pricing & Availability

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539175-5MG
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      Plastic ampoule 5 mg
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      Description
      OverviewA tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity). Shown to be a weak inhibitor of trypsin-like proteasomal activity.
      Catalogue Number539175
      Brand Family Calbiochem®
      SynonymsZ-GPFL-CHO
      References
      ReferencesOberdorf, J., et al. 2001. Biochemistry 40, 13397.
      Cardozo, C., et al. 1999. Biochemistry 38, 9768.
      Eleuteri, A.M., et al. 1997. J. Biol. Chem. 272, 11824.
      Orlowski, M., et al. 1997. Biochemistry 36, 13946.
      Vinitsky, A., et al. 1994. J. Biol. Chem. 269, 29860.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      Hill FormulaC₃₀H₃₈N₄O₆
      Chemical formulaC₃₀H₃₈N₄O₆
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetbranched chain amino acid preferring,small neutral amino acid preferring, chymotrypsin-like activities
      Primary Target K<sub>i</sub>1.5 µM, 2.3 µM, and 40.5 µM against branched chain amino acid preferring, small neutral amino acid preferring, and chymotrypsin-like activities of proteasomes, respectively
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceZ-Gly-Pro-Phe-Leu-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Proteasome Inhibitor IV - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Proteasome Inhibitor IV - Calbiochem Certificates of Analysis

      TitleLot Number
      539175

      References

      Reference overview
      Oberdorf, J., et al. 2001. Biochemistry 40, 13397.
      Cardozo, C., et al. 1999. Biochemistry 38, 9768.
      Eleuteri, A.M., et al. 1997. J. Biol. Chem. 272, 11824.
      Orlowski, M., et al. 1997. Biochemistry 36, 13946.
      Vinitsky, A., et al. 1994. J. Biol. Chem. 269, 29860.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-October-2009 RFH
      SynonymsZ-GPFL-CHO
      DescriptionA tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity). Shown to be a weak inhibitor of trypsin-like proteasomal activity.
      FormWhite lyophilized solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₀H₃₈N₄O₆
      Peptide SequenceZ-Gly-Pro-Phe-Leu-CHO
      Purity≥90% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesOberdorf, J., et al. 2001. Biochemistry 40, 13397.
      Cardozo, C., et al. 1999. Biochemistry 38, 9768.
      Eleuteri, A.M., et al. 1997. J. Biol. Chem. 272, 11824.
      Orlowski, M., et al. 1997. Biochemistry 36, 13946.
      Vinitsky, A., et al. 1994. J. Biol. Chem. 269, 29860.