539163 Proteasome Inhibitor III - Calbiochem

539163
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₅H₄₂BN₃O₆ 179324-22-2

Pricing & Availability

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539163-100UG
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      Glass bottle 100 μg
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      Description
      OverviewA boronic acid-based, reversible proteasome inhibitor that is structurally similar to MG-132 (Cat. No. 474790) but displays much higher potency (Ki = 30 pM vs. 4 nM for MG-132).
      Catalogue Number539163
      Brand Family Calbiochem®
      SynonymsMG-262, Z-LLL-B(OH)₂
      References
      ReferencesAdams, J., et al. 1998. Bioorg. Med. Chem. Lett. 8, 333.
      Mc Cormack, T., et al. 1997. J. Biol. Chem. 272, 26103.
      Product Information
      CAS number179324-22-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₅H₄₂BN₃O₆
      Chemical formulaC₂₅H₄₂BN₃O₆
      ReversibleY
      Quality LevelMQ100
      Applications
      ApplicationProteasome Inhibitor III, CAS 179324-22-2, is a reversible proteasome inhibitor that is structurally similar to MG-132, but displays much higher potency (Ki = 30 pM vs. 4 nM for MG-132).
      Biological Information
      Primary Targetproteasome
      Primary Target K<sub>i</sub>30 pM against proteasome
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceZ-Leu-Leu-Leu-B(OH)₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Proteasome Inhibitor III - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Proteasome Inhibitor III - Calbiochem Certificates of Analysis

      TitleLot Number
      539163

      References

      Reference overview
      Adams, J., et al. 1998. Bioorg. Med. Chem. Lett. 8, 333.
      Mc Cormack, T., et al. 1997. J. Biol. Chem. 272, 26103.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-September-2008 RFH
      SynonymsMG-262, Z-LLL-B(OH)₂
      DescriptionA boronic acid-based, reversible proteasome inhibitor that is structurally similar to MG-132 (Cat. No. 474790) but displays much higher potency (Ki = 0.03 nM versus 4 nM for MG-132).
      FormWhite solid
      CAS number179324-22-2
      Chemical formulaC₂₅H₄₂BN₃O₆
      Peptide SequenceZ-Leu-Leu-Leu-B(OH)₂
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Protect from moisture
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesAdams, J., et al. 1998. Bioorg. Med. Chem. Lett. 8, 333.
      Mc Cormack, T., et al. 1997. J. Biol. Chem. 272, 26103.