528281 Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₄H₂₇ClN₂O₄ 775294-82-1

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528281-10MG
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      10 mg
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      Description
      OverviewA cell-permeable vanillin-derived pyridyl-ethanamine compound that acts as a highly potent type II Plk1 inhibitor (IC50 of 200 pM) and targets the less conserved DFG motif that is only accessible when the kinase is in its inactive DFG-out conformation, resulting in an excellent selectivity over Plk2 (IC50 >66 µM), Plk3 (IC50 = 875 nM), and aurora A kinase (no detectable effect). Shown to inhibit the proliferation of HeLa cells with an EC50 of 18 µM.
      Catalogue Number528281
      Brand Family Calbiochem®
      SynonymsN-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine
      References
      ReferencesKeppner, S., et al. 2009. ChemMedChem. 4, 1806.
      Product Information
      CAS number775294-82-1
      FormBeige solid
      Hill FormulaC₂₄H₂₇ClN₂O₄
      Chemical formulaC₂₄H₂₇ClN₂O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥94% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      528281

      References

      Reference overview
      Keppner, S., et al. 2009. ChemMedChem. 4, 1806.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2011 RFH
      SynonymsN-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine
      DescriptionA cell-permeable vanillin-derived pyridyl-ethanamine compound that acts as a highly potent type II Plk1 inhibitor (IC50 of 200 pM) and targets the less conserved DFG motif that is only accessible when the kinase is in its inactive DFG-out conformation, resulting in an excellent selectivity over Plk2 (IC50 >66 µM), Plk3 (IC50 = 875 nM), and aurora A kinase (no detectable effect). Shown to inhibit the proliferation of HeLa cells with an EC50 of 18 µM.
      FormBeige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number775294-82-1
      Chemical formulaC₂₄H₂₇ClN₂O₄
      Structure formulaStructure formula
      Purity≥94% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKeppner, S., et al. 2009. ChemMedChem. 4, 1806.