528240 Platelet Membrane Glycoproteins, IIbIIIa, Human Platelets

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528240
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528240-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewNative, platelet membrane glycoprotein IIbIIIaA from human platelets. A platelet integrin that binds to fibrinogen via the recognition sequence Arg-Gly-Asp-Ser. Acts as a receptor for such adhesive ligands as fibrinogen, fibronectin and von Willebrand factor during platelet stimulation. Glycoproteins IIb and IIIa constitute the fibrinogen receptor and are required for platelet aggregation. Glycoprotein IIb consists of two disulfide-linked subunits, GPIIbα and GPIIbβ, whereas GPIIIa has only one polypeptide chain.
      Catalogue Number528240
      Brand Family Calbiochem®
      SynonymsGPIIbIIIa, Fibrinogen Receptor, CD41/CD61
      References
      ReferencesSchwarz M., et al. 2004. J. Pharmacol. Exp. Therap. 308, 1002.
      Wippler, J., et al. 1994. J. Biol. Chem. 269, 8754.
      Product Information
      FormLiquid
      FormulationIn 100 mM NaCl, 20 mM Tris-HCl, 1 mM CaCl₂, 50% glycerol, 0.1% TRITON® X-100 Detergent, ≤0.1% sodium azide, pH 7.4.
      Quality LevelMQ100
      Applications
      Biological Information
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Avoid freeze/thaw cycles.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Platelet Membrane Glycoproteins, IIbIIIa, Human Platelets SDS

      Title

      Safety Data Sheet (SDS) 

      Platelet Membrane Glycoproteins, IIbIIIa, Human Platelets Certificates of Analysis

      TitleLot Number
      528240

      References

      Reference overview
      Schwarz M., et al. 2004. J. Pharmacol. Exp. Therap. 308, 1002.
      Wippler, J., et al. 1994. J. Biol. Chem. 269, 8754.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-January-2008 JSW
      SynonymsGPIIbIIIa, Fibrinogen Receptor, CD41/CD61
      DescriptionNative, platelet membrane glycoprotein IIbIIIaA from human platelets. A platelet integrin that binds fibrinogen via the recognition sequence Arg-Gly-Asp-Ser. Acts as a receptor for such adhesive ligands as fibrinogen, fibronectin and von Willebrand factor during platelet stimulation. Glycoproteins IIb and IIIa constitute the fibrinogen receptor and are required for platelet aggregation. Glycoprotein IIb consists of two disulfide-linked subunits, GPIIbα and GPIIbβ, whereas GPIIIa has only one polypeptide chain.
      FormLiquid
      FormulationIn 100 mM NaCl, 20 mM Tris-HCl, 1 mM CaCl₂, 50% glycerol, 0.1% TRITON® X-100 Detergent, ≤0.1% sodium azide, pH 7.4.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Avoid freeze/thaw cycles.
      Toxicity Standard Handling
      ReferencesSchwarz M., et al. 2004. J. Pharmacol. Exp. Therap. 308, 1002.
      Wippler, J., et al. 1994. J. Biol. Chem. 269, 8754.