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525185 Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
200933-14-8C₁₆H₁₆F₃NO₂S

Pricing & Availability

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525185-10MG
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      Description
      OverviewA novel sulfonamide compound that acts as a cell-permeable and specific activator of phospholipase C (PLC). Shown to stimulate the PLC-mediated intracellular Ca2+ release, inositol phosphates production, and superoxide generation in various cell types. It activates all PLC isotypes (β2, β3, γ1, γ2, and δ1) in vitro, but not heterotrimeric G proteins, PI 3-kinase, or PLD.
      Catalogue Number525185
      Brand Family Calbiochem®
      Synonymsm-3M3FBS, 2,4,6-Trimethyl-N-(m-3-trifluoromethylphenyl)benzenesulfonamide
      References
      ReferencesBae, Y.S., et al. 2003. Mol. Pharmacol. 63, 1043.
      Product Information
      CAS number200933-14-8
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₆H₁₆F₃NO₂S
      Chemical formulaC₁₆H₁₆F₃NO₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPhospholipase C (PLC)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      525185

      References

      Reference overview
      Bae, Y.S., et al. 2003. Mol. Pharmacol. 63, 1043.

      Citations

      Title
    • Eva Mortier, et al. (2005) Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions. The EMBO Journal 24, 2556-2565.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-August-2008 RFH
      Synonymsm-3M3FBS, 2,4,6-Trimethyl-N-(m-3-trifluoromethylphenyl)benzenesulfonamide
      DescriptionA cell-permeable and specific activator of phospholipase C (PLC). Reported to stimulate PLC-mediated intracellular Ca2+ release, inositol phosphate production, and superoxide generation in various cell types. Activates all PLC isotypes (β2, β3, γ1, &gamma2, and δ1) in vitro, but does not exhibit any effect on heterotrimeric G proteins, PI 3-kinase, or phospholipase D.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number200933-14-8
      Chemical formulaC₁₆H₁₆F₃NO₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (7 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
      Toxicity Carcinogenic / Teratogenic
      ReferencesBae, Y.S., et al. 2003. Mol. Pharmacol. 63, 1043.
      Citation
    • Eva Mortier, et al. (2005) Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions. The EMBO Journal 24, 2556-2565.