524718 Phosphodiesterase Inhibitor Set I - Calbiochem

Overview

Replacement Information

Key Specifications Table

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524718-1SET
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      Description
      OverviewA convenient set of inhibitors that are selective for PDE types I, III, IV, and V. Contains 10 mg of 8-Methoxymethyl-3-isobutyl-1-methylxanthine (Cat. No. 454202), a Ca2+/CaM-dependent PDE (PDE I) inhibitor; 1 mg of 4-{[3′,4′-(Methylenedioxy)benzyl]amino}-6-methoxyquinazoline (Cat. No. 475250), a cGMP-specific PDE (PDE V) inhibitor; 5 mg of Rolipram (Cat. No. 557330), a cAMP-specific PDE (PDE IV) inhibitor; and 10 mg of Trequinsin, Hydrochloride (Cat. No. 382425), a cGMP-inhibited PDE (PDE III) inhibitor. Supplied with data sheet.
      Catalogue Number524718
      Brand Family Calbiochem®
      SynonymsPDE Inhibitor Set
      Application Data
      References
      ReferencesTakase, Y., et al. 1994. J. Med. Chem. 37, 2106.
      Underwood, D.C., et al. 1994. J. Pharmacol. Exp. Ther. 270, 250.
      Wells, J.N. and Miller, J.R. 1988. Methods Enzymol. 159, 489.
      Ruppert, D. and Weithmann, K.U. 1982. Life Sciences 31, 2037.
      Product Information
      FormSolid
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPDE I, PDE III, PDE IV, PDE V
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Multiple Toxicity Values, refer to MSDS
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution of each inhibitor, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Phosphodiesterase Inhibitor Set I - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Phosphodiesterase Inhibitor Set I - Calbiochem Certificates of Analysis

      TitleLot Number
      524718

      References

      Reference overview
      Takase, Y., et al. 1994. J. Med. Chem. 37, 2106.
      Underwood, D.C., et al. 1994. J. Pharmacol. Exp. Ther. 270, 250.
      Wells, J.N. and Miller, J.R. 1988. Methods Enzymol. 159, 489.
      Ruppert, D. and Weithmann, K.U. 1982. Life Sciences 31, 2037.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-September-2009 RFH
      SynonymsPDE Inhibitor Set
      Application Data
      DescriptionPhosphodiesterases (PDEs) play an important role in the regulation of cAMP and cGMP levels in the cell. At least five PDE isozymes have been characterized that are differentially expressed and regulated in different cell types: Ca2+-calmodulin-dependent (PDE I); cGMP-stimulated (PDE II); cGMP-inhibited (PDE III); cAMP-specific (PDE IV); cGMP-specific (PDE V). These isozymes exhibit significant homology in their catalytic domain. The cyclic nucleotides are important regulators of many different cellular processes. They are involved in inflammation, asthma, and cardiovascular complications. Hence, specific inhibitors of the PDE isozymes have a potential for use as therapeutic agents. The Phosphodiesterase Inhibitor Set I contains the following inhibitors that are selective for PDE types l, III, IV, and V:

      • 8-Methoxymethyl-3-isobutyl-1-methylxanthine(8-Methoxymethyl-IBMX) (Cat. No. 454202), 10 mg
      • 4-{[3',4'-(Methylenedioxy) benzyl]amino}-6-methoxyquinazoline (Cat. No. 475250), 1 mg
      • Rolipram (Cat. No. 557330), 5 mg
      • Trequinsin, Hydrochloride (Cat. No. 382425), 10 mg
      FormSolid
      SolubilitySee properties table for specific solvent and recommended stock concentration.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution of each inhibitor, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Multiple Toxicity Values, refer to MSDS
      ReferencesTakase, Y., et al. 1994. J. Med. Chem. 37, 2106.
      Underwood, D.C., et al. 1994. J. Pharmacol. Exp. Ther. 270, 250.
      Wells, J.N. and Miller, J.R. 1988. Methods Enzymol. 159, 489.
      Ruppert, D. and Weithmann, K.U. 1982. Life Sciences 31, 2037.