52332 Phenylmethylsulfonyl Fluoride - CAS 329-98-6 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₇H₇FO₂S 329-98-6

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
52332-1GM
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      Alu drum 1 gm
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      52332-25GM
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          Fibre case 25 gm
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          52332-5GM
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              Description
              OverviewIrreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor, see AEBSF (Cat. No. 101500).
              Catalogue Number52332
              Brand Family Calbiochem®
              SynonymsBenzylsulfonyl Fluoride, PMSF
              References
              ReferencesSeitz, R., et al. 1993. Int. J. Cancer 53, 514.
              Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
              Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
              Chang, C.T., et al. 1992. Biochem. Int. 28, 707.
              Product Information
              CAS number329-98-6
              ATP CompetitiveN
              FormWhite to off-white crystalline solid
              Hill FormulaC₇H₇FO₂S
              Chemical formulaC₇H₇FO₂S
              Reconstitutiont½ = 1 hour at pH 7.5. Effective concentration: 50 μM.
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ200
              Applications
              Biological Information
              Primary Targetserine proteases
              Purity≥99% by GC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSXT8040000
              Safety Information
              R PhraseR: 34

              Causes burns.
              S PhraseS: 26-36/37/39-45

              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Wear suitable protective clothing, gloves and eye/face protection.
              In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Corrosive
              Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
              Storage +15°C to +30°C
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Phenylmethylsulfonyl Fluoride - CAS 329-98-6 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Phenylmethylsulfonyl Fluoride - CAS 329-98-6 - Calbiochem Certificates of Analysis

              TitleLot Number
              52332

              References

              Reference overview
              Seitz, R., et al. 1993. Int. J. Cancer 53, 514.
              Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
              Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
              Chang, C.T., et al. 1992. Biochem. Int. 28, 707.

              Citations

              Title
            • Sun, G., et al. 2007. Journal of Bacteriology 189, 6222.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision19-August-2008 RFH
              SynonymsBenzylsulfonyl Fluoride, PMSF
              DescriptionIrreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. Effective at a concentration of 50 µM.
              FormWhite to off-white crystalline solid
              CAS number329-98-6
              RTECSXT8040000
              Chemical formulaC₇H₇FO₂S
              Structure formulaStructure formula
              Purity≥99% by GC
              SolubilityEthanol, isopropanol, or methanol
              Storage +15°C to +30°C
              Protect from moisture
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
              Toxicity Corrosive
              ReferencesSeitz, R., et al. 1993. Int. J. Cancer 53, 514.
              Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
              Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
              Chang, C.T., et al. 1992. Biochem. Int. 28, 707.
              Citation
            • Sun, G., et al. 2007. Journal of Bacteriology 189, 6222.