531294 Perk Inhibitor III, LDN-0070977 - Calbiochem

A cell-permeable, reversible, and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC₅₀ = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a.

Perk Inhibitor III, LDN-0070977 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PKR-like ER kinase Inhibitor, LDN-0070977, LDN0070977, LDN 0070977

Primary Target: PERK
531294
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₂H₈N₂O

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.31294.0001
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          		 Glass bottle 10 mg
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          Description
          OverviewA cell-permeable tricyclic heterocycle oxime that acts as a reversible and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC50 = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a. Shown to reduce thapsigargin-induced elF2a phosphorylation in mouse embryonic fibroblasts over a wide range. Does not exhibit any cellular toxicity up to 50 µM levels.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number531294
          Brand Family Calbiochem®
          SynonymsPKR-like ER kinase Inhibitor, LDN-0070977, LDN0070977, LDN 0070977
          References
          ReferencesPytel, D., et al. 2014. J. Biomol. Screen. 19, 1024.
          Product Information
          FormOff-white powder
          Hill FormulaC₁₂H₈N₂O
          Chemical formulaC₁₂H₈N₂O
          ReversibleY
          Applications
          Biological Information
          Primary TargetPERK
          Primary Target IC<sub>50</sub>7µ
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Perk Inhibitor III, LDN-0070977 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Pytel, D., et al. 2014. J. Biomol. Screen. 19, 1024.

          Technical Info

          Title
          Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
          White Paper: Further considerations of antibody validation and usage. (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-March-2015 JSW
          SynonymsPKR-like ER kinase Inhibitor, LDN-0070977, LDN0070977, LDN 0070977
          DescriptionA cell-permeable tricyclic heterocycle oxime that acts as a reversible and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC50 = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a. Shown to reduce thapsigargin-induced elF2a phosphorylation in mouse embryonic fibroblasts over a wide range. Does not exhibit any cellular toxicity up to 50 µM levels.
          FormOff-white powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₂H₈N₂O
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesPytel, D., et al. 2014. J. Biomol. Screen. 19, 1024.