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506350 Pam₃Cys-Ser-(Lys)₄, Hydrochloride

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506350
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506350-2MG
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      Plastic ampoule 2 mg
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      Description
      OverviewA cell-permeable, water-soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide, and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. Acts as a selective agonist of TLR2 (Toll-like receptor 2).
      Catalogue Number506350
      Brand Family Calbiochem®
      Synonyms(S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys₄-OH, 3HCl, P₃CSK₄, 3HCl, Pam₃Cys-SK₄, 3HCl, Pam3CSK4, TLR1/TLR2 Agonist I
      References
      ReferencesBarrenschee, M., et al. 2010. PLoS One. 5, e13889.
      Zahringer, U., et al. 2008. Immunology. 213, 205.
      Toshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
      Muller, M.R., et al. 2001. Immunology 103, 49.
      Vergne, I., and Cezanne, L. 1999. Eur. J. Biochem. 264, 369.
      Diaz-Guerra, M.J., et al. 1996. J. Biol. Chem. 271, 30114.
      Offermanns, S., et al. 1992. Biochem. J. 282, 551.
      Seifert, R., et al. 1990. Biochem. J. 267, 795.
      Hoffmann, P., et al. 1989. Biol. Chem. Hoppe. Seyler. 370, 575.
      Product Information
      CAS number112208-00-1
      FormLyophilized solid
      Hill FormulaC₈₁H₁₅₆N₁₀O₁₃S • 3 HCl
      Chemical formulaC₈₁H₁₅₆N₁₀O₁₃S • 3 HCl
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Pam₃Cys-Ser-(Lys)₄, Hydrochloride SDS

      Title

      Safety Data Sheet (SDS) 

      Pam₃Cys-Ser-(Lys)₄, Hydrochloride Certificates of Analysis

      TitleLot Number
      506350

      References

      Reference overview
      Barrenschee, M., et al. 2010. PLoS One. 5, e13889.
      Zahringer, U., et al. 2008. Immunology. 213, 205.
      Toshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
      Muller, M.R., et al. 2001. Immunology 103, 49.
      Vergne, I., and Cezanne, L. 1999. Eur. J. Biochem. 264, 369.
      Diaz-Guerra, M.J., et al. 1996. J. Biol. Chem. 271, 30114.
      Offermanns, S., et al. 1992. Biochem. J. 282, 551.
      Seifert, R., et al. 1990. Biochem. J. 267, 795.
      Hoffmann, P., et al. 1989. Biol. Chem. Hoppe. Seyler. 370, 575.

      Citations

      Title
    • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-April-2018 JSW
      Synonyms(S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys₄-OH, 3HCl, P₃CSK₄, 3HCl, Pam₃Cys-SK₄, 3HCl, Pam3CSK4, TLR1/TLR2 Agonist I
      DescriptionA cell-permeable, water-soluble, synthetic, cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation, and activates ERK1/2 and MEK1/2. Acts as a selective TLR-2 (Toll-like receptor 2) agonist.
      FormLyophilized solid
      CAS number112208-00-1
      Chemical formulaC₈₁H₁₅₆N₁₀O₁₃S • 3 HCl
      Purity≥90% by HPLC
      SolubilityH₂O (2 mg/ml)
      Storage -20°C
      Protect from moisture
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      ReferencesBarrenschee, M., et al. 2010. PLoS One. 5, e13889.
      Zahringer, U., et al. 2008. Immunology. 213, 205.
      Toshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
      Muller, M.R., et al. 2001. Immunology 103, 49.
      Vergne, I., and Cezanne, L. 1999. Eur. J. Biochem. 264, 369.
      Diaz-Guerra, M.J., et al. 1996. J. Biol. Chem. 271, 30114.
      Offermanns, S., et al. 1992. Biochem. J. 282, 551.
      Seifert, R., et al. 1990. Biochem. J. 267, 795.
      Hoffmann, P., et al. 1989. Biol. Chem. Hoppe. Seyler. 370, 575.
      Citation
    • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.