580555 Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem

580555
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₇H₅₁NO₁₄ 33069-62-4

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      580555-100MG
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          Plastic ampoule 100 mg
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          580555-25MG
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              Plastic ampoule 25 mg
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              580555-5MG
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                  Glass bottle 5 mg
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                  Description
                  OverviewAntitumor and antileukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
                  Catalogue Number580555
                  Brand Family Calbiochem®
                  SynonymsBaccatin III N-benzyl-β-phenylisoserine Ester, TAXOL®
                  References
                  ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
                  Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
                  Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
                  Hornback, N.B., et al. 1994. In Vivo 8, 819.
                  Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
                  Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
                  Ding, A.H., et al. 1990. Science 248, 370.
                  Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
                  Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
                  Product Information
                  CAS number33069-62-4
                  ATP CompetitiveN
                  FormWhite solid
                  Hill FormulaC₄₇H₅₁NO₁₄
                  Chemical formulaC₄₇H₅₁NO₁₄
                  ReversibleN
                  Structure formula ImageStructure formula Image
                  Quality LevelMQ100
                  Applications
                  Biological Information
                  Primary TargetPromotes assembly of microtubules and inhibits tubulins disassembly
                  Purity≥97% by HPLC
                  Physicochemical Information
                  Cell permeableN
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  RTECSDA8340700
                  Safety Information
                  R PhraseR: 37/38-41-46-60

                  Irritating to respiratory system and skin.
                  Risk of serious damage to eyes.
                  May cause heritable genetic damage.
                  May impair fertility.
                  S PhraseS: 22-26-36/37/39-45

                  Do not breathe dust.
                  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
                  Wear suitable protective clothing, gloves and eye/face protection.
                  In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Carcinogenic / Teratogenic
                  Storage -20°C
                  Protect from Light Protect from light
                  Protect from Moisture Protect from moisture
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem Certificates of Analysis

                  TitleLot Number
                  580555

                  References

                  Reference overview
                  Derry, W.B., et al. 1995. Biochemistry 34, 2203.
                  Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
                  Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
                  Hornback, N.B., et al. 1994. In Vivo 8, 819.
                  Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
                  Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
                  Ding, A.H., et al. 1990. Science 248, 370.
                  Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
                  Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.

                  Brochure

                  Title
                  Paclitaxel Technical Bulletin
                  Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision19-May-2008 RFH
                  SynonymsBaccatin III N-benzyl-β-phenylisoserine Ester, TAXOL®
                  DescriptionAntitumor and anti-leukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
                  FormWhite solid
                  CAS number33069-62-4
                  RTECSDA8340700
                  Chemical formulaC₄₇H₅₁NO₁₄
                  Structure formulaStructure formula
                  Purity≥97% by HPLC
                  SolubilityDMSO (10 mg/ml) or Methanol (1 mg/ml)
                  Storage -20°C
                  Protect from moisture
                  Protect from light
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
                  Toxicity Carcinogenic / Teratogenic
                  Merck USA index14, 6982
                  ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
                  Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
                  Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
                  Hornback, N.B., et al. 1994. In Vivo 8, 819.
                  Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
                  Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
                  Ding, A.H., et al. 1990. Science 248, 370.
                  Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
                  Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.

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                  Categories

                  Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Extracellular Matrix, Adhesion and Cytoskeletal Research Tools