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580556 Paclitaxel, Semi-Synthetic - CAS 33069-62-4 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₄₇H₅₁NO₁₄ 33069-62-4

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580556-5MG
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      Description
      OverviewA semi-synthetic form of Paclitaxel (Cat. No. 580555) having no contamination by natural taxanes. Also has reduced levels of epimerization products as contaminants.
      Catalogue Number580556
      Brand Family Calbiochem®
      References
      ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
      Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
      Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
      Hornback, N.B., et al. 1994. In Vivo 8, 819.
      Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
      Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
      Ding, A.H., et al. 1990. Science 248, 370.
      Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
      Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
      Product Information
      CAS number33069-62-4
      ATP CompetitiveN
      FormCrystalline solid
      Hill FormulaC₄₇H₅₁NO₁₄
      Chemical formulaC₄₇H₅₁NO₁₄
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPromotes assembly of microtubules and inhibits tubulin disassembly.
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDA8340700
      Safety Information
      R PhraseR: 37/38-41-46-60

      Irritating to respiratory system and skin.
      Risk of serious damage to eyes.
      May cause heritable genetic damage.
      May impair fertility.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Paclitaxel, Semi-Synthetic - CAS 33069-62-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Paclitaxel, Semi-Synthetic - CAS 33069-62-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      580556

      References

      Reference overview
      Derry, W.B., et al. 1995. Biochemistry 34, 2203.
      Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
      Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
      Hornback, N.B., et al. 1994. In Vivo 8, 819.
      Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
      Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
      Ding, A.H., et al. 1990. Science 248, 370.
      Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
      Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-May-2011 JSW
      DescriptionA semi-synthetically derived form of Paclitaxel (TAXOL®, Cat. No. 580555) having no contamination of natural taxanes. Also has less epimerization products as contaminants. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
      FormCrystalline solid
      CAS number33069-62-4
      RTECSDA8340700
      Chemical formulaC₄₇H₅₁NO₁₄
      Purity≥97% by HPLC
      SolubilityDMSO or methanol
      Storage -20°C
      Protect from moisture
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 6982
      ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
      Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
      Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
      Hornback, N.B., et al. 1994. In Vivo 8, 819.
      Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
      Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
      Ding, A.H., et al. 1990. Science 248, 370.
      Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
      Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Extracellular Matrix, Adhesion and Cytoskeletal Research Tools