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505981 PK11195 - CAS 85532-75-8 - Calbiochem

505981
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Key Specifications Table

Empirical FormulaCAS #
C₂₁H₂₁ClN₂O 85532-75-8

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      Glass bottle 10 mg
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      Description
      OverviewAn isoquinoline carboxamide that acts as a potent ligand for peripheral bezodiazepine receptor (Kd = 20 nM). Exhibits anti-inflammatory properties. Binds to monocytes and following lesioning its binding up-regulated in brain macrophages and activated microglia. Shown to enhance the susceptibility of cells to apoptosis induction by DNA damaging agents and can reverse the suppression of apoptosis by Bcl-2. Serves as a ligand of the outer membrane translocator protein and reduces mitochondrial transmembrane potential within 30 minutes of exposure (˜100 µM).
      Catalogue Number505981
      Brand Family Calbiochem®
      SynonymsTSPO Activator II, Mitochondrial Translocator Protein Activator II, PK 11195, PK-11195, PK11195
      References
      ReferencesNaoi, M., et al., 2013. J. Neural Transm. In press
      Casellas, P., et al., 2002. Neurochem. Int. 40, 475.
      Waterfield, J.D., et al., 1999. Rheumtology 38, 1068.
      Product Information
      CAS number85532-75-8
      FormWhite solid
      Hill FormulaC₂₁H₂₁ClN₂O
      Chemical formulaC₂₁H₂₁ClN₂O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetperipheral bezodiazepine receptor
      Primary Target K<sub>i</sub>20 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PK11195 - CAS 85532-75-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Naoi, M., et al., 2013. J. Neural Transm. In press
      Casellas, P., et al., 2002. Neurochem. Int. 40, 475.
      Waterfield, J.D., et al., 1999. Rheumtology 38, 1068.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-September-2013 JSW
      SynonymsTSPO Activator II, Mitochondrial Translocator Protein Activator II, PK 11195, PK-11195, PK11195
      DescriptionAn isoquinoline carboxamide that acts as a potent ligand for peripheral bezodiazepine receptor (Kd = 20 nM). Exhibits anti-inflammatory properties. Binds to monocytes and following lesioning its binding up-regulated in brain macrophages and activated microglia. Shown to enhance the susceptibility of cells to apoptosis induction by DNA damaging agents and can reverse the suppression of apoptosis by Bcl-2. Serves as a ligand of the outer membrane translocator protein and reduces mitochondrial transmembrane potential within 30 minutes of exposure (˜100 µM).
      FormWhite solid
      CAS number85532-75-8
      Chemical formulaC₂₁H₂₁ClN₂O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mM)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesNaoi, M., et al., 2013. J. Neural Transm. In press
      Casellas, P., et al., 2002. Neurochem. Int. 40, 475.
      Waterfield, J.D., et al., 1999. Rheumtology 38, 1068.