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526523 PIM1/2 Kinase Inhibitor V - CAS 327033-36-3 - Calbiochem

The PIM1/2 Kinase Inhibitor V, also referenced under CAS 327033-36-3, controls the biological activity of PIM1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione, SMI-4a

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526523
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
327033-36-3C₁₁H₆F₃NO₂S

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526523-5MG
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      Description
      OverviewA cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC50 = 24 nM and 100 nM against Pim-1 and Pim-2, respectively), while exhibiting little or no activity against a panel of 58 other kinases (≤20% inhibition at 5 µM). One hour inhibitor treatment (0.5 µM) of HEK-293T cultures at the end of a 4 hour 32PO4 incubation period results in nearly complete inhibition of the autophosphorylation of overexpressed Pim-1. Comparing to Inhibitor VI (Cat. No. 526524), Inhibitor V is less reactive towards DYRK1α (20% vs. 68% inhibition with respective inhibitor at 5 µM) and more potent in PC3 human prostate cancer cell killing (IC50 = 17 vs. 48 µM with respective inhibitor).
      Catalogue Number526523
      Brand Family Calbiochem®
      Synonyms(Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione, SMI-4a
      References
      ReferencesLin,Y., et al. 2009. Blood In press.
      Xia, Z., et al. 2009. J. Med. Chem. 52, 74.
      Product Information
      CAS number327033-36-3
      FormLight beige solid
      Hill FormulaC₁₁H₆F₃NO₂S
      Chemical formulaC₁₁H₆F₃NO₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Identification Number
      Catalog Number GTIN
      526523-5MG4055977270778

      Documentation

      PIM1/2 Kinase Inhibitor V - CAS 327033-36-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PIM1/2 Kinase Inhibitor V - CAS 327033-36-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      526523

      References

      Reference overview
      Lin,Y., et al. 2009. Blood In press.
      Xia, Z., et al. 2009. J. Med. Chem. 52, 74.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2011 RFH
      Synonyms(Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione, SMI-4a
      DescriptionA cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC50 = 24 nM and 100 nM against Pim-1 and Pim-2, respectively), while exhibiting little or no activity against a panel of 58 other kinases (≤20% inhibition at 5 µM). One h inhibitor treatment (0.5 µM) of HEK-293T cultures at the end of a 4 h 32PO4 incubation period results in nearly complete inhibition of the autophosphorylation of overexpressed Pim-1. Comparing to Inhibitor VI (Cat. No. 526524), Inhibitor V is less reactive towards DYRK1α (20% vs. 68% inhibition with respective inhibitor at 5 µM) and more potent in PC3 human prostate cancer cell killing (IC50 = 17 vs. 48 µM with respective inhibitor).
      FormLight beige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number327033-36-3
      Chemical formulaC₁₁H₆F₃NO₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesLin,Y., et al. 2009. Blood In press.
      Xia, Z., et al. 2009. J. Med. Chem. 52, 74.