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528110 PIH - CAS 737-86-0 - Calbiochem

528110
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Overview

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Key Specifications Table

Empirical FormulaCAS #
C₁₄H₁₄N₄O₃ 737-86-0

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528110-50MG
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      Description
      OverviewA cell-permeable, non-toxic tridendate iron (Fe3+) chelator of the aroyl hydrazone class. Even at low concentrations, highly effective in mobilizing Fe3+ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Deferoxamine Mesylate (Cat. No. 252750) but has greater access to mitochondrial iron. Also useful for the management of iron overload disease in experimental models. Inhibits the induction of heme containing indoleamine 2,3-dioxygenase activity.
      Catalogue Number528110
      Brand Family Calbiochem®
      Synonymspyridoxal isonicotinoyl hydrazone, Iron Chelator III
      References
      ReferencesBuss, J.L., et al. 2002. Biochem. Pharmacol. 64, 1689.
      Thomas, S.R., et al. 2001. J. Immunol. 166, 6332.
      Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta 1523, 154.
      Blaha, K., et al. 1998. Blood 11, 4368.
      Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med. 131, 306.
      Richardson, D.R.,et al. 1995. Blood 86, 4295.
      Richardson, D.R., et al. 1994. J. Lab. Clin. Med. 124, 660.
      Ponka, P., et al. 1988. Biochim. Biophys. Acta 967, 122.
      Ponka, P., et al. 1984. Biochim. Biophys. Acta 802, 477.
      Ponka, P., et al. 1979. FEBS Lett. 97, 317.
      Product Information
      CAS number737-86-0
      FormYellow solid
      Hill FormulaC₁₄H₁₄N₄O₃
      Chemical formulaC₁₄H₁₄N₄O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Acidic stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PIH - CAS 737-86-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PIH - CAS 737-86-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      528110

      References

      Reference overview
      Buss, J.L., et al. 2002. Biochem. Pharmacol. 64, 1689.
      Thomas, S.R., et al. 2001. J. Immunol. 166, 6332.
      Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta 1523, 154.
      Blaha, K., et al. 1998. Blood 11, 4368.
      Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med. 131, 306.
      Richardson, D.R.,et al. 1995. Blood 86, 4295.
      Richardson, D.R., et al. 1994. J. Lab. Clin. Med. 124, 660.
      Ponka, P., et al. 1988. Biochim. Biophys. Acta 967, 122.
      Ponka, P., et al. 1984. Biochim. Biophys. Acta 802, 477.
      Ponka, P., et al. 1979. FEBS Lett. 97, 317.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-April-2008 RFH
      Synonymspyridoxal isonicotinoyl hydrazone, Iron Chelator III
      DescriptionA cell-permeable, non-toxic, iron (Fe3+) chelator of the aroyl hydrazone class that exhibits high chelation efficacy. Highly effective in mobilizing Fe3+ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Desferrioxamine (Cat. No. 252750) but has greater access to mitochondrial iron. Prevents iron-mediated oxyradical formation and minimizes tissue damage. Reported to useful in studies of the management of iron overload disease. Inhibits the induction of heme-containing indoleamine 2,3-dioxygenase activity.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number737-86-0
      Chemical formulaC₁₄H₁₄N₄O₃
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (5 mg/ml) or slightly acidic medium
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Acidic stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesBuss, J.L., et al. 2002. Biochem. Pharmacol. 64, 1689.
      Thomas, S.R., et al. 2001. J. Immunol. 166, 6332.
      Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta 1523, 154.
      Blaha, K., et al. 1998. Blood 11, 4368.
      Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med. 131, 306.
      Richardson, D.R.,et al. 1995. Blood 86, 4295.
      Richardson, D.R., et al. 1994. J. Lab. Clin. Med. 124, 660.
      Ponka, P., et al. 1988. Biochim. Biophys. Acta 967, 122.
      Ponka, P., et al. 1984. Biochim. Biophys. Acta 802, 477.
      Ponka, P., et al. 1979. FEBS Lett. 97, 317.