533657 PI4KIIIβ Inhibitor, BF738735 - Calbiochem

533657
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₁H₁₉FN₄O₃S

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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable imidazo-pyrazine based compound that acts as a potent and reversible inhibitor of PI4KIIIβ (IC50 = 5.7 nM). Displays excellent selectivity over PI4KIIIα (IC50 = 1.7 µM) and several other lipid kinases (IC50 > 10 µM). Shown to dose-dependently decrease PI4P levels, reduce oxysterol-binding protein (OSBP) localization to replication organelles (ROs) and inhibit cholesterol shuttling to ROs (at 1 µM in BGM and HeLaR19 cells transfected with CVB3) at multiplicity of infection (MOI). Exhibits uniformly potent and broad spectrum antienteroviral activity across a wide range of species (EC50 = 4-31 nM) and is inactive against RNA, DNA, and retroviruses.
      Catalogue Number533657
      Brand Family Calbiochem®
      Synonyms2-Fluoro-4-(2-methyl-8-(3-(methylsulfonyl)benzylamino)imidazo[1,2-a]pyrazin-3-yl)phenol, Phosphatidylinositol-phosphate-4-Kinase III β Inhibitor, BF-738735
      DescriptionPI4KIIIβ Inhibitor, BF738735
      References
      ReferencesStrating, J.R.P.M., et al. 2015. Cell Reports. 10, 600.
      MacLeod, A.M., et al. 2013. ACS Med. Chem. Lett. 4, 585.
      Product Information
      FormLight grey powder
      Hill FormulaC₂₁H₁₉FN₄O₃S
      Chemical formulaC₂₁H₁₉FN₄O₃S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPI4KIII&beta
      Primary Target IC<sub>50</sub>5.7 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PI4KIIIβ Inhibitor, BF738735 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Strating, J.R.P.M., et al. 2015. Cell Reports. 10, 600.
      MacLeod, A.M., et al. 2013. ACS Med. Chem. Lett. 4, 585.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-June-2016 JSW
      Synonyms2-Fluoro-4-(2-methyl-8-(3-(methylsulfonyl)benzylamino)imidazo[1,2-a]pyrazin-3-yl)phenol, Phosphatidylinositol-phosphate-4-Kinase III β Inhibitor, BF-738735
      DescriptionA cell-permeable imidazo-pyrazine based compound that acts as a potent and reversible inhibitor of PI4KIIIβ (IC50 = 5.7 nM). Displays excellent selectivity over PI4KIIIα (IC50 = 1.7 µM) and several other lipid kinases (IC50 > 10 µM). Shown to dose-dependently decrease PI4P levels, reduce oxysterol-binding protein (OSBP) localization to replication organelles (ROs) and inhibit cholesterol shuttling to ROs (at 1 µM in BGM and HeLaR19 cells transfected with CVB3) at multiplicity of infection (MOI). Exhibits uniformly potent and broad spectrum antienteroviral activity across a wide range of species (EC50 = 4-31 nM) and is inactive against RNA, DNA, and retroviruses.
      FormLight grey powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₁H₁₉FN₄O₃S
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesStrating, J.R.P.M., et al. 2015. Cell Reports. 10, 600.
      MacLeod, A.M., et al. 2013. ACS Med. Chem. Lett. 4, 585.