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504632 PHCCC - CAS 1161205-27-1 - Calbiochem

PHCCC - CAS 1161205-27-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-1,1a,7,7a-Tetrahydro-7-(hydroxyimino)-N-phenylcyclopropa[b]chromene-1a-carboxamide

Primary Target: mGlu₄ receptors
504632
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1161205-27-1C₁₇H₁₄N₂O₃

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      Description
      OverviewA potent positive allosteric modulator selective for mGlu4 receptors (EC50 = 3 µM). Also, a less potent agonist of mGlu6 receptors (EC50 = 15 µM). Biologically active admitted systematically. Often used in assessing the functional roles of mGlu4 receptors or group III mGlu receptors in a variety of research areas, such as epileptic seizures, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
      Catalogue Number504632
      Brand Family Calbiochem®
      Synonyms(E)-1,1a,7,7a-Tetrahydro-7-(hydroxyimino)-N-phenylcyclopropa[b]chromene-1a-carboxamide
      References
      ReferencesOh, H., et al. 2013. Psychopharmacol. 1, 9.
      Dickerson, W., 2012. Neurodegen. Diseases Manag. 2, 221.
      Le Poul, E., et al. 2012. J. Pharmacol. & Exp. Therap. 343, 167.
      Szczurowska, E., 2012. Physiol. Res. 61, 619.
      Beqollari, D., et al. 2008. Eur. J. Pharmacol. 589, 4.
      Niswender, M., et al. 2008. Mol. Pharmacol. 74, 1345.
      Stachowicz, K., et al. 2004. Eur. J. Pharmacol. 498, 153.
      Maj, M., et al. 2003. Neuropharmacol. 45, 895.
      Marino, J., et al. 2003. PNAS. 100, 13668.
      Product Information
      CAS number1161205-27-1
      FormWhite solid
      Hill FormulaC₁₇H₁₄N₂O₃
      Chemical formulaC₁₇H₁₄N₂O₃
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetmGlu₄ receptors
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PHCCC - CAS 1161205-27-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Oh, H., et al. 2013. Psychopharmacol. 1, 9.
      Dickerson, W., 2012. Neurodegen. Diseases Manag. 2, 221.
      Le Poul, E., et al. 2012. J. Pharmacol. & Exp. Therap. 343, 167.
      Szczurowska, E., 2012. Physiol. Res. 61, 619.
      Beqollari, D., et al. 2008. Eur. J. Pharmacol. 589, 4.
      Niswender, M., et al. 2008. Mol. Pharmacol. 74, 1345.
      Stachowicz, K., et al. 2004. Eur. J. Pharmacol. 498, 153.
      Maj, M., et al. 2003. Neuropharmacol. 45, 895.
      Marino, J., et al. 2003. PNAS. 100, 13668.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-July-2013 JSW
      Synonyms(E)-1,1a,7,7a-Tetrahydro-7-(hydroxyimino)-N-phenylcyclopropa[b]chromene-1a-carboxamide
      DescriptionA potent positive allosteric modulator selective for mGlu4 receptors (EC50 = 3 µM). Also, a less potent agonist of mGlu6 receptors (EC50 = 15 µM). Biologically active admitted systematically. Often used in assessing the functional roles of mGlu4 receptors or group III mGlu receptors in a variety of research areas, such as epileptic seizures, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
      FormWhite solid
      CAS number1161205-27-1
      Chemical formulaC₁₇H₁₄N₂O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesOh, H., et al. 2013. Psychopharmacol. 1, 9.
      Dickerson, W., 2012. Neurodegen. Diseases Manag. 2, 221.
      Le Poul, E., et al. 2012. J. Pharmacol. & Exp. Therap. 343, 167.
      Szczurowska, E., 2012. Physiol. Res. 61, 619.
      Beqollari, D., et al. 2008. Eur. J. Pharmacol. 589, 4.
      Niswender, M., et al. 2008. Mol. Pharmacol. 74, 1345.
      Stachowicz, K., et al. 2004. Eur. J. Pharmacol. 498, 153.
      Maj, M., et al. 2003. Neuropharmacol. 45, 895.
      Marino, J., et al. 2003. PNAS. 100, 13668.