528150 PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₇H₁₇N₃O₂ · HCl 344458-15-7

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
528150-1MG
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      528150-5MG
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          Description
          OverviewA cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50 = 200 µM). Does not act as an antioxidant at higher concentrations (1 µM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke. Also available as a 20 mM solution in H2O(Cat. No. 528151).
          Catalogue Number528150
          Brand Family Calbiochem®
          References
          ReferencesAbdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
          Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
          Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.
          Product Information
          CAS number344458-15-7
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₇H₁₇N₃O₂ · HCl
          Chemical formulaC₁₇H₁₇N₃O₂ · HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationPARP Inhibitor VIII, PJ34, CAS 344458-15-7, is a cell-permeable, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM).
          Biological Information
          Primary TargetPARP
          Primary Target IC<sub>50</sub>EC50 = 20 nM inhibiting poly(ADP-ribose) polymerase (PARP)
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          528150

          References

          Reference overview
          Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
          Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
          Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-January-2008 JSW
          DescriptionA water-soluble phenanthridinone-derivative that acts as a potent anti-inflammatory agent and an inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC50 = 200 µM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 µM to 10 µM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC50 = 20 nM). Exhibits neuroprotective effects in in vivo and in vitro models of stroke.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number344458-15-7
          Chemical formulaC₁₇H₁₇N₃O₂ · HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (5 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesAbdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
          Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
          Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.