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530647 Orai1/CRAC Blocker, Cpd5J-4 - Calbiochem

530647
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₆H₁₂N₂O₃S

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      Glass bottle 10 mg
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      Description
      OverviewA non-toxic thiourea derivative that acts as a blocker of Orai1, the pore subunit of Ca2+-release-activated Ca2+ (CRAC) in T cells. Exhibits a strong blocking effect on store-operated Ca2+ entry in HeLa-O+S cells and in Th17 cells. Preferentially reduces Th17 differentiation and ameliorates Th17-mediated autoimmune disease. Blocks the infiltration of T cells into the CNS and reduces the number of IL-17 producing cells. Also shown to reduce the expression of retinoic acid receptor-related orphan receptors a (RORa) and RORgt. Reduces the symptoms and delays the onset of experimental autoimmune encephalomyelitis (EAE) in myelin oligodendrocyte glycoproteins 35-55 (MOG35-55) immunized mice (2 mg/kg, i.p.).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530647
      Brand Family Calbiochem®
      SynonymsOrai1 Inhibitor, CRAC Inhibitor, Ca2+ release-activated Ca2+ (CRAC) channel blocker
      References
      ReferencesKim, K., et al. 2014. J Immunol. 192, 110.
      Product Information
      FormOff-white powder
      Hill FormulaC₁₆H₁₂N₂O₃S
      Chemical formulaC₁₆H₁₂N₂O₃S
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetOrail1
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Orai1/CRAC Blocker, Cpd5J-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Kim, K., et al. 2014. J Immunol. 192, 110.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2014 JSW
      SynonymsOrai1 Inhibitor, CRAC Inhibitor, Ca2+ release-activated Ca2+ (CRAC) channel blocker
      DescriptionA non-toxic thiourea derivative that acts as a blocker of Orai1, the pore subunit of Ca2+-release-activated Ca2+ (CRAC) in T cells. Exhibits a strong blocking effect on store-operated Ca2+ entry in HeLa-O+S cells and in Th17 cells. Preferentially reduces Th17 differentiation and ameliorates Th17-mediated autoimmune disease. Blocks the infiltration of T cells into the CNS and reduces the number of IL-17 producing cells. Also shown to reduce the expression of retinoic acid receptor-related orphan receptors a (RORa) and RORgt. Reduces the symptoms and delays the onset of experimental autoimmune encephalomyelitis (EAE) in myelin oligodendrocyte glycoproteins 35-55 (MOG35-55) immunized mice (2 mg/kg, i.p.).
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₆H₁₂N₂O₃S
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKim, K., et al. 2014. J Immunol. 192, 110.