Millipore Sigma Vibrant Logo

OptiScale® Capsule Filters for Aseptic Processing Applications

OptiScale® capsules, with a large variety of filtration media options, are a family of convenient, disposable filters ideal for media selection, process screening and scaling.

Overview

Specifications

Ordering Information

Go
OptiScale® with Durapore® 0.1 µmClear Sorting & Filtering Show Filter
Catalog NumberConnections (Inlet/Outlet)Pack Size
SVVLA47FF319 mm (3/4 in.) Sanitary Flange 3 Show Pricing & Availability
SVVLA47FH319 mm (3/4 in.) Sanitary Flange/6 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SVVLA47HH36 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SVVLA25NB6Female Luer Lok/ Male Luer Lok 6 Show Pricing & Availability

Back To Top

OptiScale® with Durapore® 0.22 µmClear Sorting & Filtering Show Filter
Catalog NumberConnections (Inlet/Outlet)Pack Size
SVGLA47FF319 mm (3/4 in.) Sanitary Flange 3 Show Pricing & Availability
SVGLA47FH319 mm (3/4 in.) Sanitary Flange/6 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SVGLA47HH36 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SVGLA25NB6Female Luer Lok/ Male Luer Lok 6 Show Pricing & Availability

Back To Top

OptiScale® with Multilayer Durapore® 0.45 µm/0.22 µmClear Sorting & Filtering Show Filter
Catalog NumberConnections (Inlet/Outlet)Pack Size
SHGLA47FF319 mm (3/4 in.) Sanitary Flange 3 Show Pricing & Availability
SHGLA47FH319 mm (3/4 in.) Sanitary Flange/6 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SHGLA47HH36 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SHGLA25NB6Female Luer Lok/ Male Luer Lok 6 Show Pricing & Availability

Back To Top

OptiScale® with Durapore® 0.45 μmClear Sorting & Filtering Show Filter
Catalog NumberConnections (Inlet/Outlet)Pack Size
SVHLA25NB6Female Luer Lok/ Male Luer Lok 6 Show Pricing & Availability

Back To Top

OptiScale® with Durapore® 0.45 μm with PrefilterClear Sorting & Filtering Show Filter
Catalog NumberConnections (Inlet/Outlet)Pack Size
SHGLA25NB6Female Luer Lok/ Male Luer Lok 6 Show Pricing & Availability

Back To Top

OptiScale®with Durapore® Multimedia 0.2 µm (nominal)/0.22 µmClear Sorting & Filtering Show Filter
Catalog NumberConnections (Inlet/Outlet)Pack Size
SV03A47FF319 mm (3/4 in.) Sanitary Flange 3 Show Pricing & Availability
SV03A47FH319 mm (3/4 in.) Sanitary Flange/6 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SV03A47HH36 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SV03A25NB6Female Luer Lok/ Male Luer Lok 6 Show Pricing & Availability

Back To Top

OptiScale® with Durapore® Multimedia 0.5 µm (nominal)/0.2 µm (nominal)/0.22 µmClear Sorting & Filtering Show Filter
Catalog NumberConnections (Inlet/Outlet)Pack Size
SVSSA47FF319 mm (3/4 in.) Sanitary Flange 3 Show Pricing & Availability
SVSSA47FH319 mm (3/4 in.) Sanitary Flange/6 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SVSSA47HH36 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SVSSA25NB6Female Luer Lok/ Male Luer Lok 6 Show Pricing & Availability

Back To Top

OptiScale®with Durapore® Multimedia 1.2 µm (nominal)/0.2 µm (nominal)/0.22 µmClear Sorting & Filtering Show Filter
Catalog NumberConnections (Inlet/Outlet)Pack Size
SVSXA47FF319 mm (3/4 in.) Sanitary Flange 3 Show Pricing & Availability
SVSXA47FH319 mm (3/4 in.) Sanitary Flange/6 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SVSXA47HH36 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SVSXA25NB6Female Luer Lok/ Male Luer Lok 6 Show Pricing & Availability

Back To Top

OptiScale® with Durapore® Multimedia 0.5 µm (nominal)/0.22 µmClear Sorting & Filtering Show Filter
Catalog NumberConnections (Inlet/Outlet)Pack Size
SV06A47FF319 mm (3/4 in.) Sanitary Flange 3 Show Pricing & Availability
SV06A47FH319 mm (3/4 in.) Sanitary Flange/6 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SV06A47HH36 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SV06A25NB6Female Luer Lok/ Male Luer Lok 6 Show Pricing & Availability

Back To Top

OptiScale® with Durapore® Multimedia 1.2 µm (nominal)/0.5 µm (nominal)/0.22 µmClear Sorting & Filtering Show Filter
Catalog NumberConnections (Inlet/Outlet)Pack Size
SVSCA47FF319 mm (3/4 in.) Sanitary Flange 3 Show Pricing & Availability
SVSCA47FH319 mm (3/4 in.) Sanitary Flange/6 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SVSCA47HH36 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SVSCA25NB6Female Luer Lok/ Male Luer Lok 6 Show Pricing & Availability

Back To Top

OptiScale® with Durapore® Multimedia 1.2 µm (nominal)/0.22 µmClear Sorting & Filtering Show Filter
Catalog NumberConnections (Inlet/Outlet)Pack Size
SV19A47FF319 mm (3/4 in.) Sanitary Flange 3 Show Pricing & Availability
SV19A47FH319 mm (3/4 in.) Sanitary Flange/6 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SV19A47HH36 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SV19A25NB6Female Luer Lok/ Male Luer Lok 6 Show Pricing & Availability

Back To Top

OptiScale® with Millipore Express® SHF 0.2 µmClear Sorting & Filtering Show Filter
Catalog NumberConnections (Inlet/Outlet)Pack Size
SGEPA47FF319 mm (3/4 in.) Sanitary Flange 3 Show Pricing & Availability
SGEPA47FH319 mm (3/4 in.) Sanitary Flange/6 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SGEPA47HH36 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SGEPA25NB6Female Luer Lok/ Male Luer Lok 6 Show Pricing & Availability

Back To Top

OptiScale®with Millipore Express® SHC 0.5 + 0.2 µmClear Sorting & Filtering Show Filter
Catalog NumberConnections (Inlet/Outlet)Pack Size
SHGEA47FF319 mm (3/4 in.) Sanitary Flange 3 Show Pricing & Availability
SHGEA47FH319 mm (3/4 in.) Sanitary Flange/6 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SHGEA47HH36 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SHGEA25NB6Female Luer Lok/ Male Luer Lok 6 Show Pricing & Availability

Back To Top

OptiScale® with Millipore Express® SHR 0.5 + 0.1 µmClear Sorting & Filtering Show Filter
Catalog NumberConnections (Inlet/Outlet)Pack Size
SHVEA47FF319 mm (3/4 in.) Sanitary Flange 3 Show Pricing & Availability
SHVEA47FH319 mm (3/4 in.) Sanitary Flange/6 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SHVEA47HH36 mm (1/4 in.) Hose Barb 3 Show Pricing & Availability
SHVEA25NB6Female Luer Lok/ Male Luer Lok 6 Show Pricing & Availability

Back To Top

OptiScale® with Millipore Express® SHR 0.1 μmClear Sorting & Filtering Show Filter
Catalog NumberConnections (Inlet/Outlet)Pack Size
SVEPA25NB6Female Luer Lok/ Male Luer Lok 6 Show Pricing & Availability

Back To Top

Optiscale® with Millipore Express® PHF 0.2 µmClear Sorting & Filtering Show Filter
Catalog NumberConnections (Inlet/Outlet)Pack Size
SPGEA25NB6Female Luer Lok/ Male Luer Lok 6 Show Pricing & Availability

Back To Top

Documentation

Technical Info

Title
Application Note: Cell Culture Media Filtration - Filter Selection and Sizing

Data Sheet

Title
Durapore® Family Guide
Millipore Express® PHF Hydrophilic Filters (EMD)
Millipore Express® SHC Hydrophilic Filters
Millipore Express® SHF Hydrophilic Filters (EMD)
Millipore Express® SHR Hydrophilic Filters

FAQ

QuestionAnswer
What is the compatibility of Durapore with high pH solutions?The upper recommended pH limit for Durapore membranes is 10. At pH >10, the hydrophilization layer of the membrane may become subject to hydrolysis. The extent of hydrolysis is a function of time, temperature , concentration and time of exposure. Upon exposure to high pH, the hydrophylization layer can swell which could result in a loss of permeability or flux. The hydrolysis of the hydrophilic layer will also lead to increased extractables from the membrane.
What are Millipore's general recommendations for filtering high pH solutions?For applications involving pH > 10, Millipore recommends the use or our PES membranes Express SHF or Express SHC. For information on these filters :

Express SHF: http://www.millipore.com/catalogue.nsf/docs/C8873
Express SHC: http://www.millipore.com/catalogue.nsf/docs/C9146
How can I differentiate filter plugging due to air bubbles, particulates, surface tension, inappropriate filter size, etc.?Air locking will occur when filtration is initiated without adequate venting or when air bubbles become trapped in fluid lines. Air will pass easily through a dry hydrophillic or hydrophobic filter. However, when a filter is wet and air is applied to a surface, the air will remain until it is manually moved upstream by venting or until the bubble point of the filter is reached. Bubble point is defined as the pressure at which gas displaces liquid for the largest set of filter pores and is able to flow through the pores. Air locking reduces the effective filtration area of the filter and thus reduces the flow rate.

Surface tension refers to the strong cohesive forces present between molecules at the surface of a liquid. The higher the surface tension, the more force is required to force fluid through the membrane..

Innapropriate filter size will can cause a filter to plug prematurely. Filter pore size is chosen based on the application. If the application requires a sterile fluid, than a 0.22 micron membrane would be used for standard solutions that have bacterial bioburden. A 0.1 micron filter would be used for applications where mycoplasma is a concern. Where virus contamination is a concern, ultrafiltration would be required. The selection of a filter pore size that is smaller than that required for the application will cause a decrease in filter capacity and an increase in cost.

User Guides

Title
OptiScale®-25 Capsule Filter User Guide
OptiScale®-25 Capsule Filter with Millipore Express® PHF Membrane

Related Products & Applications

Product Families

Related Products By: Application Facete

Related Products By: Brand Facete

Categories

Biopharmaceutical Manufacturing > Downstream Processing > Sterile Filtration > Sterile Liquid > Durapore