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495455 Oligomycin - CAS 1404-19-9 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₄₅H₇₄O₁₁ 1404-19-9

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495455-10MG
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      Plastic ampoule 10 mg
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      Description
      OverviewA mixture of A, B, and C isomers. A macrolide antibiotic that inhibits membrane-bound mitochondrial ATP synthase, preventing phosphoryl group transfer. Induces apoptosis in cultured human lymphoblastoid and other mammalian cells.
      Catalogue Number495455
      Brand Family Calbiochem®
      References
      ReferencesWolvetang, E.J., et al. 1994. FEBS Lett. 339, 40.
      Amoroso, S., et al. 1993. J. Pharmacol. Exp. Ther. 264, 515.
      Brustovetsky, N.N., et al. 1993. FEBS Lett. 315, 233.
      Nagamune, H., et al. 1993. Biochim. Biophys. Acta 1141, 231.
      Product Information
      CAS number1404-19-9
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₄₅H₇₄O₁₁
      Chemical formulaC₄₅H₇₄O₁₁
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationOligomycin, CAS 1404-19-9, is a macrolide antibiotic that inhibits membrane-bound mitochondrial ATP synthase and prevents phosphoryl group transfer. It is a mixture of A, B, and C isomers.
      Biological Information
      Primary TargetMembrane-bound mitochondrial ATPase (F1)
      Purity≥90% by HPLC (mixture of A, B, and C isomers)
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSRK3325000
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Oligomycin - CAS 1404-19-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Oligomycin - CAS 1404-19-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      495455

      References

      Reference overview
      Wolvetang, E.J., et al. 1994. FEBS Lett. 339, 40.
      Amoroso, S., et al. 1993. J. Pharmacol. Exp. Ther. 264, 515.
      Brustovetsky, N.N., et al. 1993. FEBS Lett. 315, 233.
      Nagamune, H., et al. 1993. Biochim. Biophys. Acta 1141, 231.

      Brochure

      Title
      Antibiotics Profiler
      Mitochondrial Metabolism Modulators (MilliporeSigma)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-July-2012 JSW
      DescriptionA mixture of A, B, and C isomers. A macrolide antibiotic that inhibits membrane-bound mitochondrial ATP synthase, preventing phosphoryl group transfer. Induces apoptosis in cultured human lymphoblastoid and other mammalian cells.
      FormWhite solid
      CAS number1404-19-9
      RTECSRK3325000
      Chemical formulaC₄₅H₇₄O₁₁
      Structure formulaStructure formula
      Purity≥90% by HPLC (mixture of A, B, and C isomers)
      SolubilityEthanol (250 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Irritant
      Merck USA index14, 6833
      ReferencesWolvetang, E.J., et al. 1994. FEBS Lett. 339, 40.
      Amoroso, S., et al. 1993. J. Pharmacol. Exp. Ther. 264, 515.
      Brustovetsky, N.N., et al. 1993. FEBS Lett. 315, 233.
      Nagamune, H., et al. 1993. Biochim. Biophys. Acta 1141, 231.