459620 Okadaic Acid, Sodium Salt - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₄₄H₆₇O₁₃ · Na

Pricing & Availability

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459620-25UG
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      Alu drum 25 μg
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      Description
      OverviewWater-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A.
      Catalogue Number459620
      Brand Family Calbiochem®
      References
      ReferencesGjertsen, B.T., et al. 1994. J. Cell Sci. 107, 3363.
      Kiguchi, K., et al. 1994. Cell Growth Differentiation 5, 995.
      Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
      Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
      Kreienbuhl, P., et al. 1992. Blood 80, 2911.
      Normura, M., et al. 1992. Biochemistry 31, 11915.
      Song, Q., et al. 1992. J. Cell Physiol. 153, 550.
      Tada, Y., et al. 1992. Immunopharmacol. 24, 17.
      Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
      Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
      Cohen, P., and Cohen, P.T.W. 1989. J. Biol. Chem. 254 21435.
      Haystead, T.A. et al. 1989. Nature 337, 78.
      Product Information
      ATP CompetitiveN
      FormWhite solid - colorless film
      Hill FormulaC₄₄H₆₇O₁₃ · Na
      Chemical formulaC₄₄H₆₇O₁₃ · Na
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationOkadaic Acid, Sodium Salt, is a water-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A.
      Biological Information
      Primary TargetPP1, PP2
      Primary Target IC<sub>50</sub>10-15 nM, 0.1 nM against protein phosphatase 1, protein phosphatase 2A, respectively
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 23/24/25-38

      Toxic by inhalation, in contact with skin and if swallowed.
      Irritating to skin.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Okadaic Acid, Sodium Salt - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Okadaic Acid, Sodium Salt - Calbiochem Certificates of Analysis

      TitleLot Number
      459620

      References

      Reference overview
      Gjertsen, B.T., et al. 1994. J. Cell Sci. 107, 3363.
      Kiguchi, K., et al. 1994. Cell Growth Differentiation 5, 995.
      Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
      Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
      Kreienbuhl, P., et al. 1992. Blood 80, 2911.
      Normura, M., et al. 1992. Biochemistry 31, 11915.
      Song, Q., et al. 1992. J. Cell Physiol. 153, 550.
      Tada, Y., et al. 1992. Immunopharmacol. 24, 17.
      Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
      Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
      Cohen, P., and Cohen, P.T.W. 1989. J. Biol. Chem. 254 21435.
      Haystead, T.A. et al. 1989. Nature 337, 78.

      Brochure

      Title
      Protein Phosphatases Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-September-2014 JSW
      DescriptionWater-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A.
      FormWhite solid - colorless film
      Chemical formulaC₄₄H₆₇O₁₃ · Na
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (20 mg/ml), Ethanol (20 mg/ml), or H₂O (1 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Toxic
      ReferencesGjertsen, B.T., et al. 1994. J. Cell Sci. 107, 3363.
      Kiguchi, K., et al. 1994. Cell Growth Differentiation 5, 995.
      Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
      Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
      Kreienbuhl, P., et al. 1992. Blood 80, 2911.
      Normura, M., et al. 1992. Biochemistry 31, 11915.
      Song, Q., et al. 1992. J. Cell Physiol. 153, 550.
      Tada, Y., et al. 1992. Immunopharmacol. 24, 17.
      Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
      Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
      Cohen, P., and Cohen, P.T.W. 1989. J. Biol. Chem. 254 21435.
      Haystead, T.A. et al. 1989. Nature 337, 78.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Phosphatase Inhibitors