491207 Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₃₁H₃₅N₂O₁₁ · Na 1476-53-5

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491207-10GM
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      491207-1GM
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          Description
          OverviewDNA gyrase inhibitor used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases. Also a potent inhibitor of ADP ribosylation eliminates the wild-type pMG110 plasmid from E. coli.
          Catalogue Number491207
          Brand Family Calbiochem®
          References
          ReferencesMarcu, M.G., et al. 2000. J. Natl. Cancer Inst. 92, 242.
          Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp. 42, 1911.
          Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
          Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
          Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
          Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.
          Product Information
          CAS number1476-53-5
          ATP CompetitiveN
          FormWhite to yellow solid
          Hill FormulaC₃₁H₃₅N₂O₁₁ · Na
          Chemical formulaC₃₁H₃₅N₂O₁₁ · Na
          ReversibleN
          Quality LevelMQ100
          Applications
          ApplicationNovobiocin, Sodium Salt, CAS 1476-53-5, is a DNA gyrase inhibitor used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases.
          Biological Information
          Primary Targetretrovirus RNA-dependent DNA polymerases
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSRD5425000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for 3 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem Certificates of Analysis

          TitleLot Number
          491207

          References

          Reference overview
          Marcu, M.G., et al. 2000. J. Natl. Cancer Inst. 92, 242.
          Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp. 42, 1911.
          Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
          Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
          Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
          Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-May-2018 JSW
          DescriptionA DNA gyrase inhibitor that can be used for the production of positively supercoiled plasma DNA. Targets the nucleotide-binding site of gyrase B. Exhibits antibacterial properties. Inhibits retrovirus RNA-dependent DNA polymerases. Inhibits LPS-induced production of pro-inflammatory cytokines. Reported to act as a potent inhibitor of ADP ribosylation. Also inhibits protein synthesis and alters the phosphorylation state of several cytosolic proteins.
          FormWhite to yellow solid
          CAS number1476-53-5
          RTECSRD5425000
          Chemical formulaC₃₁H₃₅N₂O₁₁ · Na
          Purity≥90% by HPLC
          SolubilityH₂O (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for 3 months at 4°C.
          Toxicity Harmful
          Merck USA index14, 6722
          ReferencesMarcu, M.G., et al. 2000. J. Natl. Cancer Inst. 92, 242.
          Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp. 42, 1911.
          Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
          Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
          Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
          Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > DNA and RNA Polymerase Inhibitors