481990 Nigericin, Sodium Salt, Streptomyces hygroscopicus - CAS 28643-80-3 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₄₀H₆₇O₁₁ . Na 28643-80-3

Pricing & Availability

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481990-10MG
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      481990-5MG
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          Description
          OverviewDisrupts the membrane potential and stimulates ATPase activity in mitochondria. Transports monovalent cations across membranes with the following specificity: K+>Rb+>Cs+>>Na+.
          Catalogue Number481990
          Brand Family Calbiochem®
          SynonymsAntibiotic K178
          References
          ReferencesMoriyama, Y., et al. 1994. J. Biochem. 115, 213.
          Eytan, G.D., et al. 1990. J. Biol. Chem. 265, 12949.
          Alonso, M.A., and Carrasco, L. 1981. FEBS Lett. 127, 112.
          Product Information
          CAS number28643-80-3
          ATP CompetitiveN
          FormLyophilized
          Hill FormulaC₄₀H₆₇O₁₁ . Na
          Chemical formulaC₄₀H₆₇O₁₁ . Na
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationNigericin, Sodium Salt, Streptomyces hygroscopicus, CAS 28643-80-3, is an antibiotic K+ ionophore that disrupts the membrane potential and stimulates ATPase activity in mitochondria.
          Biological Information
          Primary TargetDisrupts the membrane potential and stimulates ATPase activity in mitochondria.
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSQT6825000
          Safety Information
          R PhraseR: 23/24/25-36/37/38

          Toxic by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 22-36/37/39-45

          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze. Stock solutions are stable for 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Nigericin, Sodium Salt, Streptomyces hygroscopicus - CAS 28643-80-3 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Nigericin, Sodium Salt, Streptomyces hygroscopicus - CAS 28643-80-3 - Calbiochem Certificates of Analysis

          TitleLot Number
          481990

          References

          Reference overview
          Moriyama, Y., et al. 1994. J. Biochem. 115, 213.
          Eytan, G.D., et al. 1990. J. Biol. Chem. 265, 12949.
          Alonso, M.A., and Carrasco, L. 1981. FEBS Lett. 127, 112.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-May-2008 RFH
          SynonymsAntibiotic K178
          DescriptionA monocarboxylate that catalyzes the electroneutral exchange of an alkali metal for H+ (antiport). Transports monovalent cations across membranes with the following specificities: K+>Rb+>Cs+>>Na+. An antibiotic that kills bacteria by facilitating the diffusion of ions across membranes. Disrupts the membrane potential and stimulates mitochondrial ATPase activity.
          FormLyophilized
          CAS number28643-80-3
          RTECSQT6825000
          Chemical formulaC₄₀H₆₇O₁₁ . Na
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityCHCl₃, ethanol, or ethyl acetate
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze. Stock solutions are stable for 1 month at -20°C.
          Toxicity Toxic
          Merck USA index14, 6541
          ReferencesMoriyama, Y., et al. 1994. J. Biochem. 115, 213.
          Eytan, G.D., et al. 1990. J. Biol. Chem. 265, 12949.
          Alonso, M.A., and Carrasco, L. 1981. FEBS Lett. 127, 112.