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494105 Neuroprotectant, OBA-09 - Calbiochem

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494105-25MG
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      Glass bottle 25 mg
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      Description
      OverviewA brain-permeable ester of pyruvate and salicylic acid that exhibits anti-oxidative and anti-excitotoxic properties. Following its uptake by the brain tissue, it releases pyruvate and salicylic acid via ester hydrolysis (t1/2 of 43 min in serum). Exerts strong neuroprotective effects in the post-ischemic brain and significantly reduces infarct volume (27% and 65% reduction in 6 and 12 hours following i.v. administration of 10 mg/kg in a rat model). Also, blocks Zn2+-induced neuronal cell death. Its neuroprotective effects are attributed to its ability to prevent NAD- and ATP-depletion in post-ischemic brain and suppression of NF-κB activity by reducing IκB-α degradation.
      Catalogue Number494105
      Brand Family Calbiochem®
      Synonyms2-(2-Oxopropanoyloxy)Benzoic Acid
      References
      ReferencesKim, S.W., et al. 2011. Mol. Pharmacol. 79, 220.
      Product Information
      FormWhite solid
      Hill FormulaC₁₀H₈O₅
      Chemical formulaC₁₀H₈O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Neuroprotectant, OBA-09 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Neuroprotectant, OBA-09 - Calbiochem Certificates of Analysis

      TitleLot Number
      494105

      References

      Reference overview
      Kim, S.W., et al. 2011. Mol. Pharmacol. 79, 220.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-August-2012 JSW
      Synonyms2-(2-Oxopropanoyloxy)Benzoic Acid
      DescriptionA brain-permeable ester of pyruvate and salicylic acid that exhibits anti-oxidative and anti-excitotoxic properties. Following its uptake by the brain tissue, it releases pyruvate and salicylic acid via ester hydrolysis (t1/2 of 43 min in serum). Exerts strong neuroprotective effects in the post-ischemic brain and significantly reduces infarct volume (27% and 65% reduction in 6 and 12 hours following i.v. administration of 10 mg/kg in a rat model). Also, blocks Zn2+-induced neuronal cell death. Its neuroprotective effects are attributed to its ability to prevent NAD- and ATP-depletion in post-ischemic brain and suppression of NF-κB activity by reducing IκB-α degradation.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₀H₈O₅
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKim, S.W., et al. 2011. Mol. Pharmacol. 79, 220.