505020 NS3763 - CAS 70553-45-6 - Calbiochem

505020
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Key Specifications Table

Empirical FormulaCAS #
C₂₂H₁₆N₂O₆ 70553-45-6

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      Glass bottle 5 mg
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      Description
      OverviewA potent non-competitive antagonist highly selective for homomeric GluK5 subtype of kainate receptors (IC50 = 1.6 µM) over homomeric GLUK6 receptors (IC50 > 30 µM). Negligible effect on native AMPA and NMDA receptors (IC50 > 30 µM). Used for assessing functional roles of GluK5 subtype of kainate receptors in ischemic brain injury, anxiety and stress-related disorders, and synaptic neurotransmissions.
      Catalogue Number505020
      Brand Family Calbiochem®
      References
      ReferencesHarvey, H., et al. 2012. Pharmacol. Biochem. & Beh. 100, 775.
      Chamberlain, L., 2012. Hippocampus. 22, 555.
      Matute, C., 2011. CNS Neurosci. & Ther. 17, 661.
      Xu, J., et al. 2008. J. Biol. Chem. 283, 29355.
      Christensen, J.K., et al. 2004. J. Pharmacol. & Exp. Ther. 309, 1003.
      Product Information
      CAS number 70553-45-6
      FormOff-white solid
      Hill FormulaC₂₂H₁₆N₂O₆
      Chemical formulaC₂₂H₁₆N₂O₆
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetGluk5
      Primary Target IC<sub>50</sub>1.6 →M
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      NS3763 - CAS 70553-45-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Harvey, H., et al. 2012. Pharmacol. Biochem. & Beh. 100, 775.
      Chamberlain, L., 2012. Hippocampus. 22, 555.
      Matute, C., 2011. CNS Neurosci. & Ther. 17, 661.
      Xu, J., et al. 2008. J. Biol. Chem. 283, 29355.
      Christensen, J.K., et al. 2004. J. Pharmacol. & Exp. Ther. 309, 1003.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2013 JSW
      DescriptionA potent non-competitive antagonist highly selective for homomeric GluK5 subtype of kainate receptors (IC50 = 1.6 µM) over homomeric GLUK6 receptors (IC50 > 30 µM). Negligible effect on native AMPA and NMDA receptors (IC50 > 30 µM). Used for assessing functional roles of GluK5 subtype of kainate receptors in ischemic brain injury, anxiety and stress-related disorders, and synaptic neurotransmissions.
      FormOff-white solid
      CAS number 70553-45-6
      Chemical formulaC₂₂H₁₆N₂O₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mM)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHarvey, H., et al. 2012. Pharmacol. Biochem. & Beh. 100, 775.
      Chamberlain, L., 2012. Hippocampus. 22, 555.
      Matute, C., 2011. CNS Neurosci. & Ther. 17, 661.
      Xu, J., et al. 2008. J. Biol. Chem. 283, 29355.
      Christensen, J.K., et al. 2004. J. Pharmacol. & Exp. Ther. 309, 1003.