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487957 NOC-18 - CAS 146724-94-9 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₄H₁₃N₅O₂ 146724-94-9

Pricing & Availability

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487957-10MG
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      Plastic ampoule 10 mg
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      Description
      OverviewA nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952) and NOC-12 (Cat. No. 487955) but with an enhanced half-life. Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu2+ in vitro. Half-life (t½) in PBS, pH 7.4 is 3400 minutes at 22°C. Relatively stable in alkaline solution (pH ≥10.0).
      Catalogue Number487957
      Brand Family Calbiochem®
      SynonymsDETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate
      References
      ReferencesSeccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306.
      Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103.
      Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519.
      Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287.
      Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.
      Product Information
      CAS number146724-94-9
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₄H₁₃N₅O₂
      Chemical formulaC₄H₁₃N₅O₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetA nitric oxide (NO) donor
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in NaOH, aliquot and freeze (-20°C). Stock solutions in NaOH are stable for up to 24 h at -20°C. Stock solutions in H₂O or PBS, pH 7.4 are unstable; reconstitute just prior to use.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      NOC-18 - CAS 146724-94-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      NOC-18 - CAS 146724-94-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      487957

      References

      Reference overview
      Seccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306.
      Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103.
      Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519.
      Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287.
      Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-July-2019 JSW
      SynonymsDETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate
      DescriptionA nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952), and NOC-12 (Cat. No. 487955) but with enhanced half-life for NO release (t½ = 3400 min; PBS, pH 7.4, 22°C). Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu2+ in vitro.
      FormWhite solid
      CAS number146724-94-9
      Chemical formulaC₄H₁₃N₅O₂
      Structure formulaStructure formula
      Purity≥90% by HPLC
      Solubility0.1N NaOH (10 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in NaOH, aliquot and freeze (-20°C). Stock solutions in NaOH are stable for up to 24 h at -20°C. Stock solutions in H₂O or PBS, pH 7.4 are unstable; reconstitute just prior to use.
      Toxicity Irritant
      ReferencesSeccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306.
      Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103.
      Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519.
      Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287.
      Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Biochemicals > Nucleotides, Nucleosides, Purines, Pyrimidines and Nucleic Acids > Nitric Oxide Donors/Precursors