481406 NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₂H₂₀N₄O 545380-34-5

Pricing & Availability

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481406-1MG
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      Description
      OverviewA cell-permeable quinazoline compound that acts as a highly potent inhibitor of NF-κB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC50 = 7 nM in murine splenocytes). Shown to exhibit anti-inflammatory effect on carrageenin-induced paw edema in rat. A 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481407) in DMSO is also available.
      Catalogue Number481406
      Brand Family Calbiochem®
      Synonyms6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
      References
      ReferencesTobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.
      Product Information
      CAS number545380-34-5
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₂H₂₀N₄O
      Chemical formulaC₂₂H₂₀N₄O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNF-κB transcriptional activation
      Primary Target IC<sub>50</sub>11 nM against NF-κB transcriptional activation in Jurkat cells
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      481406

      References

      Reference overview
      Tobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-October-2007 JSW
      Synonyms6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
      DescriptionA cell-permeable quinazoline compound that acts as a potent inhibitor of NF-κB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC50 = 7 nM in murine splenocytes). Does not exhibit cellular cytotoxicity even at concentrations as high as 10 µM. Reported to exhibit anti-inflammatory effects on carregeenin-induced paw edema in rats.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number545380-34-5
      Chemical formulaC₂₂H₂₀N₄O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesTobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.