480030 NEMO-Binding Domain Binding Peptide, Cell-Permeable, Negative Control - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₅₄H₂₄₉N₄₇O₄₂S

Pricing & Availability

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480030-500UG
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      Plastic ampoule 500 μg
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      Description
      OverviewA cell-permeable Antennapedia-NBD mutated (Trp739 and Trp741 replaced with Ala) fusion peptide analog of NEMO-Binding Domain Binding Peptide (Cat. No. 480025) that serves as a negative control. Shown to be defective in binding to NEMO. Does not affect the TNF-α-induced phosphorylation of c-Jun and DNA binding of the transcription factor Oct-1.
      Catalogue Number480030
      Brand Family Calbiochem®
      SynonymsDRQIKIWFQNRRMKWKK-TALDASALQTE, NBD-Binding Peptide, Cell-Permeable, Negative Control
      References
      ReferencesJimi, E., et al. 2004. Nat. Med., 10, 617.
      May, M.J., et al. 2000. Science 289, 1550.
      Product Information
      ATP CompetitiveN
      FormLyophilized off-white solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₅₄H₂₄₉N₄₇O₄₂S
      Chemical formulaC₁₅₄H₂₄₉N₄₇O₄₂S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNegative control defective in binding to NEMO
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH₂N-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Ala-Ser-Ala-Leu-Gln-Thr-Glu-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      NEMO-Binding Domain Binding Peptide, Cell-Permeable, Negative Control - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      NEMO-Binding Domain Binding Peptide, Cell-Permeable, Negative Control - Calbiochem Certificates of Analysis

      TitleLot Number
      480030

      References

      Reference overview
      Jimi, E., et al. 2004. Nat. Med., 10, 617.
      May, M.J., et al. 2000. Science 289, 1550.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-August-2008 RFH
      SynonymsDRQIKIWFQNRRMKWKK-TALDASALQTE, NBD-Binding Peptide, Cell-Permeable, Negative Control
      DescriptionA cell-permeable, Antennapedia-NBD mutated (Trp739 → Ala and Trp741 → Ala) fusion peptide analog of NEMO-Binding Domain Binding peptide (Cat. No. 480025) that serves as a negative control. Reported to be defective in binding to NEMO. Does not affect the TNF-α-induced phosphorylation of c-Jun or DNA binding of the transcription factor Oct-1.
      FormLyophilized off-white solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₅₄H₂₄₉N₄₇O₄₂S
      Peptide SequenceH₂N-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Ala-Ser-Ala-Leu-Gln-Thr-Glu-OH
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml). Note: This peptide will precipitate when added to tissue culture medium even at 100 µM concentrations; however, sufficient material will stay in solution to permeate cells.
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJimi, E., et al. 2004. Nat. Med., 10, 617.
      May, M.J., et al. 2000. Science 289, 1550.