480026 NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₂₃H₁₉₇N₄₇O₃₂

Pricing & Availability

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480026-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC50 ~ 50 µM in HCT116 cells). Acts by interfering with the formation of active IKK complex and thereby prevents IκBα phosphorylation and its subsequent proteasomal degradation. Also blocks LPS-mediated increase in inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activities. Colon-targeted capsules containing CTP-NBD are shown to reduce 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rodent models (4.5 mg/kg/,p.o.) in vivo and diminish activities of myeloperoxidase and several inflammatory mediators. Antennapedia fused NBD cell-permeable peptide is also available (Cat. No. 480025).
      Catalogue Number480026
      Brand Family Calbiochem®
      SynonymsNEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD
      References
      ReferencesHong, S., et al. 2012. Mol. Pharm. 9, 1310.
      Kim, D., et al. 2006. Exp. Cell Res. 312, 1277.
      Product Information
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₂₃H₁₉₇N₄₇O₃₂
      Hygroscopic Hygroscopic
      ReversibleY
      Sold on the basis of peptide contentY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNEMO-binding peptide
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide ContentY
      Peptide SequenceAc-YGRRARRRARRTALDWSWLQTE-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem Certificates of Analysis

      TitleLot Number
      480026

      References

      Reference overview
      Hong, S., et al. 2012. Mol. Pharm. 9, 1310.
      Kim, D., et al. 2006. Exp. Cell Res. 312, 1277.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-June-2017 JSW
      SynonymsNEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD
      DescriptionA cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC50 ~ 50 µM in HCT116 cells). Acts by interfering with the formation of active IKK complex and thereby prevents IκBα phosphorylation and its subsequent proteasomal degradation. Also blocks LPS-mediated increase in inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activities. Colon-targeted capsules containing CTP-NBD are shown to reduce 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rodent models (4.5 mg/kg/,p.o.) in vivo and diminish activities of myeloperoxidase and several inflammatory mediators. Antennapedia fused NBD cell-permeable peptide is also available (Cat. No. 480025).
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Peptide SequenceAc-YGRRARRRARRTALDWSWLQTE-NH₂
      Purity≥95% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesHong, S., et al. 2012. Mol. Pharm. 9, 1310.
      Kim, D., et al. 2006. Exp. Cell Res. 312, 1277.