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Description
Overview
A cell permeable phenylaminopyrimidine derived compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 2 (Mnk2, Ki = 370 nM. Displays high selectivity over CDK2 (Ki >10 µM) and CDK9 (Ki = 1.66 µM). Shown to block the phosphorylation of elF4E in and effectively inhibit the proliferation of MV4-11 cells (GI50 = 780 nM) by inducing a cell cycle arrest at G0/G1 phase. Diminishes the expression of Mcl-1 and causes PARP cleavage in A2780 ovarian cancer cells.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number
531206
Brand Family
Calbiochem®
Synonyms
Mitogen-activated protein kinase-interacting kinase 2
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
19-December-2014 JSW
Synonyms
Mitogen-activated protein kinase-interacting kinase 2
Description
A cell permeable phenylaminopyrimidine derived compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 2 (Mnk2, Ki = 370 nM in MV4-11 cells). Displays high selectivity over CDK2 (Ki >10 µM) and CDK9 (Ki = 1.66 µM). Shown to block the phosphorylation of elF4E in and effectively inhibit the proliferation of MV4-11 cells (GI50 = 780 nM) by inducing a cell cycle arrest at G0/G1 phase. Diminishes the expression of Mcl-1 and causes PARP cleavage in A2780 ovarian cancer cells.
Form
Yellow powder
Intert gas (Yes/No)
Packaged under inert gas
Chemical formula
C₁₇H₁₈N₄O₃S
Purity
>98% by HPLC
Solubility
DMSO (50 mg/ml)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.