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Description
Overview
Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Forms covalent adducts into deoxyguanine and guanine under acidic conditions. Induces apoptosis in gastric cancer cells. Blocks the cell cycle at the G2 phase.
Catalogue Number
47589
Brand Family
Calbiochem®
Synonyms
Mitocin C, MMC
References
References
Kruyt, F.A., et al. 1996. Blood 89, 938. Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst.87, 1394. Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24. Kawasaki, S., et al. 1992. Jpn. J. Cancer Res.83, 899. Malkinson, A.M., et al. 1992. Cancer Res.52, 4752. McEvoy, J.L., et al. 1992. J. Bacteriol.174, 5471. Tomasz, M., et al. 1987. Science235, 1204.
Wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, store in the refrigerator (4°C) for short-term storage and in a freezer (-20°C) for longer term. Stock solutions are stable for up to 2 weeks at 4°C and up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Documentation
Mitomycin C, Streptomyces caespitosus - CAS 50-07-7 - Calbiochem SDS
Mitomycin C, Streptomyces caespitosus - CAS 50-07-7 - Calbiochem Certificates of Analysis
Title
Lot Number
47589
References
Reference overview
Kruyt, F.A., et al. 1996. Blood 89, 938. Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst.87, 1394. Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24. Kawasaki, S., et al. 1992. Jpn. J. Cancer Res.83, 899. Malkinson, A.M., et al. 1992. Cancer Res.52, 4752. McEvoy, J.L., et al. 1992. J. Bacteriol.174, 5471. Tomasz, M., et al. 1987. Science235, 1204.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
15-May-2008 RFH
Synonyms
Mitocin C, MMC
Description
Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues, disrupting base pairing. Induces apoptosis in gastic cancer cells. Blocks the cell cycle at the G2 phase.
Form
Blue-violet solid
Formulation
Provided as 2 mg antibiotic and 48 mg NaCl.
CAS number
50-07-7
RTECS
CN0700000
Chemical formula
C₁₅H₁₈N₄O₅
Structure formula
Purity
≥95% by HPLC
Solubility
H₂O (1 mg/ml)
Storage
+2°C to +8°C
Protect from light
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, store in the refrigerator (4°C) for short-term storage and in a freezer (-20°C) for longer term. Stock solutions are stable for up to 2 weeks at 4°C and up to 3 months at -20°C.
Toxicity
Highly Toxic & Carcinogenic / Teratogenic
Merck USA index
14, 6215
References
Kruyt, F.A., et al. 1996. Blood 89, 938. Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst.87, 1394. Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24. Kawasaki, S., et al. 1992. Jpn. J. Cancer Res.83, 899. Malkinson, A.M., et al. 1992. Cancer Res.52, 4752. McEvoy, J.L., et al. 1992. J. Bacteriol.174, 5471. Tomasz, M., et al. 1987. Science235, 1204.
