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Description
Overview
A cell permeable naphthalene derivative that promotes the translocation of ATF2 from nucleus to mitochondria via PKCe that results in mitochondrial membrane leakage and cell death in melanoma cells (WM793 and UACC903). Diminishes cell motility and anchorage-free growth in melanoma cells (<90% at 10µM) and reduces their migration in an ATF2-dependent manner. Shown to reduce ATF2 phosphorylation on Thr52, 69, and 71. However, it does not affect the activity of Erk1/2, Akt, pan-PKC. Cells expressing ATF2T52E do not exhibit any loss of mitochondrial membrane potential. Does not induce apoptosis in normal melanocytes even at high concentrations (~20 mM) and has no effect on the localization or translocation of p53, STAT3, or b-catenin.
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity
Standard Handling
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Documentation
References
Reference overview
Varsano, T., et al, 2013, Clin. Cancer Res.19, 2710.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A cell permeable naphthalene derivative that promotes the translocation of ATF2 from nucleus to mitochondria via PKCe that results in mitochondrial membrane leakage and cell death in melanoma cells (WM793 and UACC903). Diminishes cell motility and anchorage-free growth in melanoma cells (<90% at 10µM) and reduces their migration in an ATF2-dependent manner. Shown to reduce ATF2 phosphorylation on Thr52, 69, and 71. However, it does not affect the activity of Erk1/2, Akt, pan-PKC. Cells expressing ATF2T52E do not exhibit any loss of mitochondrial membrane potential. Does not induce apoptosis in normal melanocytes even at high concentrations (~20 mM) and has no effect on the localization or translocation of p53, STAT3, or b-catenin.
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
Chemical formula
C₂₁H₂₃NO₂
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (2.5 mg/ml). Warming is required for complete solubilization.
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Varsano, T., et al, 2013, Clin. Cancer Res.19, 2710.
