475851 Mitaplatin - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₀H₂₂Cl₆N₄O₆Pt

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
475851-25MG
Retrieving availability...
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Glass bottle 25 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity needs to be mulitiple of
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewA cell-permeable Pt(IV) compound that, upon reduction inside cells, yields two molecules of the PDK (pyruvate dehydrogenase kinase) inhibitor DCA/dichloroacetate and one molecule of the apoptosis inducer Cisplatin (Cat. No. 232120). While the dual prodrug nature of Mitaplatin is shown to result in increased cell killing than Cisplatin in the human ovarian carcinoma A2780/CP70 cultures (IC50 = 3.34 and 6.0, respectively), the anticancer potency of Mitaplatin is often weaker than Cisplatin in other cancer cells tested, presumably due to insufficient prodrug reduction in these cells.

      Note: Carboplatin, Cisplatin, and other platinum drugs are reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Solubilization with DMSO prior to culture treatment is not recommended.
      Catalogue Number475851
      Brand Family Calbiochem®
      Synonymsc,c,t-[Pt(NH₃)₂Cl₂(O₂CCHCl₂)₂]
      References
      ReferencesHall, M.D., et al. 2014. Cancer Res. In press.
      Dhar, S., and Lippard, S.J., 2009. Proc. Natl. Acad. Sci. USA 106, 22199.
      Product Information
      FormOff-white to cream solid
      Hill FormulaC₁₀H₂₂Cl₆N₄O₆Pt
      Chemical formulaC₁₀H₂₂Cl₆N₄O₆Pt
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by NMR
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-36-45

      Do not breathe dust.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. Use only fresh DMSO for reconstitution.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Mitaplatin - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Mitaplatin - Calbiochem Certificates of Analysis

      TitleLot Number
      475851

      References

      Reference overview
      Hall, M.D., et al. 2014. Cancer Res. In press.
      Dhar, S., and Lippard, S.J., 2009. Proc. Natl. Acad. Sci. USA 106, 22199.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-July-2014 JSW
      Synonymsc,c,t-[Pt(NH₃)₂Cl₂(O₂CCHCl₂)₂]
      DescriptionA cell-permeable Pt(IV) compound that, upon reduction inside cells, yields two molecules of the PDK (pyruvate dehydrogenase kinase) inhibitor DCA/dichloroacetate and one molecule of the apoptosis inducer Cisplatin (Cat. No. 232120). While the dual prodrug nature of Mitaplatin is shown to result in increased cell killing than Cisplatin in the human ovarian carcinoma A2780/CP70 cultures (IC50 = 3.34 and 6.0, respectively), the anticancer potency of Mitaplatin is often weaker than Cisplatin in other cancer cells tested, presumably due to insufficient prodrug reduction in these cells.

      Note: Carboplatin, Cisplatin, and other platinum drugs are reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Solubilization with DMSO prior to culture treatment is not recommended.
      FormOff-white to cream solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₀H₂₂Cl₆N₄O₆Pt
      Structure formulaStructure formula
      Purity≥95% by NMR
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. Use only fresh DMSO for reconstitution.
      Toxicity Harmful
      ReferencesHall, M.D., et al. 2014. Cancer Res. In press.
      Dhar, S., and Lippard, S.J., 2009. Proc. Natl. Acad. Sci. USA 106, 22199.