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445820 Meriolin 2 - Calbiochem

Meriolin 2 primarily used in Inhibition.

Meriolin 2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-((2-Amino)pyrimidin-4-yl)-4-hydroxy-1H-pyrrolo[2,3-b]pyridine

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445820
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₁H₉N₅O

Pricing & Availability

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445820-5MG
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      		 Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable, ATP-binding site-targeting azaindolopyrimidine compound that inhibits against Cdk2/A, Cdk9/T, DYRK1A, Cdk5/p25, CK1δ/ε, Cdk1/B, and GSK-3α/β kinase activity (IC50 = 18, 18, 35, 50, 50, 57, and 500 nM, respectively). Shown to induce DEVDase activity in SH-SY5Y neuroblastoma cultures (by 5.46-fold in 24 h at 1 µM) and exhibit antiproliferative activity toward SH-SY5Y, multiple myeloma KMS-11, human embryonic kidney HEK293, colorectal adenocarcinoma LS 174T, and glioma GBM cells in vitro (IC50 = 0.41, 0.6, 0.96, 1.06, and 1.21 µM, respectively).
      Catalogue Number445820
      Brand Family Calbiochem®
      Synonyms3-((2-Amino)pyrimidin-4-yl)-4-hydroxy-1H-pyrrolo[2,3-b]pyridine
      References
      ReferencesEchalier, A., et al. 2008. J. Med. Chem. 51, 737.
      Bettayeb, K., et al. 2007. Cancer Res. 67, 8325.
      Product Information
      FormYellow solid
      Hill FormulaC₁₁H₉N₅O
      Chemical formulaC₁₁H₉N₅O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥93% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Meriolin 2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Meriolin 2 - Calbiochem Certificates of Analysis

      TitleLot Number
      445820

      References

      Reference overview
      Echalier, A., et al. 2008. J. Med. Chem. 51, 737.
      Bettayeb, K., et al. 2007. Cancer Res. 67, 8325.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-March-2011 RFH
      Synonyms3-((2-Amino)pyrimidin-4-yl)-4-hydroxy-1H-pyrrolo[2,3-b]pyridine
      DescriptionA cell-permeable, ATP-binding site-targeting azaindolopyrimidine compound that inhibits against Cdk2/A, Cdk9/T, DYRK1A, Cdk5/p25, CK1δ/ε, Cdk1/B, and GSK-3α/β kinase activity (IC50 = 18, 18, 35, 50, 50, 57, and 500 nM, respectively). Shown to induce DEVDase activity in SH-SY5Y neuroblastoma cultures (by 5.46-fold in 24 h at 1 µM) and exhibit antiproliferative activity toward SH-SY5Y, multiple myeloma KMS-11, human embryonic kidney HEK293, colorectal adenocarcinoma LS 174T, and glioma GBM cells in vitro (IC50 = 0.41, 0.6, 0.96, 1.06, and 1.21 µM, respectively).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₁H₉N₅O
      Structure formulaStructure formula
      Purity≥93% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesEchalier, A., et al. 2008. J. Med. Chem. 51, 737.
      Bettayeb, K., et al. 2007. Cancer Res. 67, 8325.