444130 Mcl-1 Inhibitor, MIM1 - Calbiochem

444130
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444130-25MG
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      Glass bottle 25 mg
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      Description
      OverviewA cell-permeable thiazolyliminopyrogallol that selectively neutralizes Mcl-1, but not Bcl-XL, antiapoptotic activity by directly targeting Mcl-1 BH3-binding site, effectively competing against Bid BH3 sequence for Mcl-1 binding (IC50 = 4.8 µM). Shown to induce caspase 3/7 activation and cell death in Mcl-1-, but not Bcl-XL-, dependent B-ALL cultures (6% vs. 82% survival, respectively; 10 µM). In comparison, ABT-737 (Cat. No. 197333) affects only Bcl-XL-, but not Mcl-1-, dependent B-ALL cells. Neither MIM1 nor ABT-737 significantly affects the survival of wild-type or Bax-/-Bak-/- MEF.
      Catalogue Number444130
      Brand Family Calbiochem®
      Synonyms4-((E)-((Z)-2-(cyclohexylimino)-4-methylthiazol-3(2H)-ylimino)methyl)benzene-1,2,3-triol, Mcl-1 Inhibitor Molecule 1
      References
      ReferencesCohen, N.A., et al. 2012. Chem. Biol. 19, 1175.
      Product Information
      FormYellow powder
      Hill FormulaC₁₇H₂₁N₃O₃S
      Chemical formulaC₁₇H₂₁N₃O₃S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMcl-1
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Mcl-1 Inhibitor, MIM1 - Calbiochem Certificates of Analysis

      TitleLot Number
      444130

      References

      Reference overview
      Cohen, N.A., et al. 2012. Chem. Biol. 19, 1175.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-July-2013 JSW
      Synonyms4-((E)-((Z)-2-(cyclohexylimino)-4-methylthiazol-3(2H)-ylimino)methyl)benzene-1,2,3-triol, Mcl-1 Inhibitor Molecule 1
      DescriptionA cell-permeable thiazolyliminopyrogallol that selectively neutralizes Mcl-1, but not Bcl-XL, antiapoptotic activity, by directly targeting Mcl-1 BH3-binding site, effectively competing against Bid BH3 sequence for Mcl-1 binding (IC50 = 4.8 µM) without affecting Bcl-XL interaction with Bad or Bid BH3 sequence (IC50 >50 µM). Shown to induce caspase 3/7 activation and cell death in Mcl-1-, but not Bcl-XL-, dependent B-ALL cultures (6% vs. 82% survival, respectively, [MIM1] = 10 µM). In comparison, ABT-737 (Cat. No. 197333) affects only Bcl-XL-, but not Mcl-1-, dependent B-ALL cultures (0% vs. 98% survival, respectively, [ABT-737] = 10 µM). Neither MIM1 nor ABT-737 significantly affects the survival of wild-type (81% and 79% survival in the presence of 10 µM respective inhibitor) or Bax-/-Bak-/- MEF (93% and 84% survival in the presence of 10 µM respective inhibitor).
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇H₂₁N₃O₃S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesCohen, N.A., et al. 2012. Chem. Biol. 19, 1175.