Millipore Sigma Vibrant Logo

454862 MNK1/2 Inhibitor II, ETP-45835 - Calbiochem

The MNK1/2 Inhibitor II, ETP-45835 controls the biological activity of MNK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MNK1/2 Inhibitor II, ETP-45835 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ETP45835, MNK Inhibitor II, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor II, 4-(3-(Piperidin-4-yl)-1H-pyrazol-5-yl)pyridine, diHCl

View Products on Sigmaaldrich.com
454862
View Pricing & Availability

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₃H₁₆N₄•2HCl

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
454862-10MG
Retrieving availability...
—
Fulfilment and delivery delayed Fulfilment and delivery delayed
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Glass bottle 10 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Description
      OverviewA cell-permeable 3,5-disubstituted pyrazolo compound that acts as a selective MNK inhibitor (IC50 = 646 and 575 nM, respectively, against MNK1 and MNK2) with much reduced or little activity against 24 other kinases (≤15% inhibition at 5 µM). Reported to exhibit good aqueous solubility (> 100 µM at pH 7.4) and inhibit the proliferation (IC50 = 17 µM) and cellular eIF4E Ser209 phosphorylation (IC50 = 4.7 µM) of MV4:11 cells.
      Catalogue Number454862
      Brand Family Calbiochem®
      SynonymsETP45835, MNK Inhibitor II, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor II, 4-(3-(Piperidin-4-yl)-1H-pyrazol-5-yl)pyridine, diHCl
      References
      ReferencesOyarzabal, J., et al. 2010. J. Med. Chem. 53, 6618.
      Product Information
      FormWhite solid
      Hill FormulaC₁₃H₁₆N₄•2HCl
      Chemical formulaC₁₃H₁₆N₄•2HCl
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MNK1/2 Inhibitor II, ETP-45835 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MNK1/2 Inhibitor II, ETP-45835 - Calbiochem Certificates of Analysis

      TitleLot Number
      454862

      References

      Reference overview
      Oyarzabal, J., et al. 2010. J. Med. Chem. 53, 6618.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-September-2012 JSW
      SynonymsETP45835, MNK Inhibitor II, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor II, 4-(3-(Piperidin-4-yl)-1H-pyrazol-5-yl)pyridine, diHCl
      DescriptionA cell-permeable 3,5-disubstituted pyrazolo compound that acts as a selective MNK inhibitor (IC50 = 646 and 575 nM, respectively, against MNK1 and MNK2) with much reduced or little activity against a panel of 24 other kinases (≤15% inhibition at 5 µM), including MNK upstream kinases B-Raf, ERK1, MEK1, and p38α. Reported to exhibit good aqueous solubility (> 100 µM at pH 7.4) and inhibit the proliferation (IC50 = 17 µM) and cellular eIF4E Ser209 phosphorylation (IC50 = 4.7 µM) of acute myeloid leukemia MV4:11 cells.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₃H₁₆N₄•2HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesOyarzabal, J., et al. 2010. J. Med. Chem. 53, 6618.