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504634 MMPIP - CAS 479077-02-6 - Calbiochem

MMPIP - CAS 479077-02-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[ 4,5-c]pyridin-4(5H)-one, Metabotropic Glutamate Receptor Type 7 Antagonist I, mGlu7 Antagonist I, mGluR7 Antagonist I

Primary Target: mGlu₇ receptors
504634
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
479077-02-6C₁₉H₁₅N₃O₃

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      Description
      OverviewA potent negative allosteric modulator highly selective for mGlu7 receptors (IC50 = 15 nM). No effect on other subtype mGlu receptors. Frequently used in studies of alcohol and cocaine addition, depression, anxiety and stress related disorders.
      Catalogue Number504634
      Brand Family Calbiochem®
      Synonyms6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[ 4,5-c]pyridin-4(5H)-one, Metabotropic Glutamate Receptor Type 7 Antagonist I, mGlu7 Antagonist I, mGluR7 Antagonist I
      References
      ReferencesPalucha-Poniewiera, A., et al. 2013. Behav. Brain Res. 238, 109.
      Bahi, A., et al. 2012. Addict. Biol. 17, 235.
      Harvey, H., et al. 2012. Pharmacol. Biochem. and Behav. 100, 775.
      Hikichi, H., et al. 2010. Eur. J. Pharmacol. 639, 106.
      Suzuki, X., et al. 2007. J. Pharmacol. Exp. Ther. 323, 147.
      Li, X., et al. 2009. Neuropsychopharmacology 34, 1783.
      Suzuki, G., et al. 2007. J. Pharmacol. Exp. Ther. 323, 147.
      Product Information
      CAS number479077-02-6
      FormWhite solid
      Hill FormulaC₁₉H₁₅N₃O₃
      Chemical formulaC₁₉H₁₅N₃O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmGlu₇ receptors
      Primary Target IC<sub>50</sub>15 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Identification Number
      Catalog Number GTIN
      5.04634.00014055977243970

      Documentation

      MMPIP - CAS 479077-02-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Palucha-Poniewiera, A., et al. 2013. Behav. Brain Res. 238, 109.
      Bahi, A., et al. 2012. Addict. Biol. 17, 235.
      Harvey, H., et al. 2012. Pharmacol. Biochem. and Behav. 100, 775.
      Hikichi, H., et al. 2010. Eur. J. Pharmacol. 639, 106.
      Suzuki, X., et al. 2007. J. Pharmacol. Exp. Ther. 323, 147.
      Li, X., et al. 2009. Neuropsychopharmacology 34, 1783.
      Suzuki, G., et al. 2007. J. Pharmacol. Exp. Ther. 323, 147.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-June-2013 JSW
      Synonyms6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[ 4,5-c]pyridin-4(5H)-one, Metabotropic Glutamate Receptor Type 7 Antagonist I, mGlu7 Antagonist I, mGluR7 Antagonist I
      DescriptionA potent negative allosteric modulator highly selective for mGlu7 receptors (IC50 = 15 nM). No effect on other subtype mGlu receptors. Frequently used in studies of alcohol and cocaine addition, depression, anxiety and stress related disorders.
      FormWhite solid
      CAS number479077-02-6
      Chemical formulaC₁₉H₁₅N₃O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPalucha-Poniewiera, A., et al. 2013. Behav. Brain Res. 238, 109.
      Bahi, A., et al. 2012. Addict. Biol. 17, 235.
      Harvey, H., et al. 2012. Pharmacol. Biochem. and Behav. 100, 775.
      Hikichi, H., et al. 2010. Eur. J. Pharmacol. 639, 106.
      Suzuki, X., et al. 2007. J. Pharmacol. Exp. Ther. 323, 147.
      Li, X., et al. 2009. Neuropsychopharmacology 34, 1783.
      Suzuki, G., et al. 2007. J. Pharmacol. Exp. Ther. 323, 147.