444290 MMP Inhibitor V - CAS 223472-31-9 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₂H₂₈N₂O₆ 223472-31-9

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444290-2MG
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      Plastic ampoule 2 mg
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      Description
      OverviewAn orally active non-peptidyl hydroxamate compound that acts as an effective broad-spectrum inhibitor against MMP-2, -3, -8, -9, -12, -13 (Ki = 0.73, 42, 1.1, 2.1, 0.45, and 1.1 nM, respectively), but not MMP-1 (IC50 = 1.6 µM), MMP-7 (Ki = 2.5 µM), or other serine proteases (no activity against chymotrypsin or plasmin at 100 µM). Widely used in studying MMP-mediated diseases development in vivo. Also reported to block P-LAP secretase activity (≥70% inhibition of P-LAP shedding at 10 µM) that is otherwise not inhibited by TIMP-1/2 in CHO cell cultures in vitro.
      Catalogue Number444290
      Brand Family Calbiochem®
      Synonyms(2S,4S)-N-Hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide, ONO-4817
      References
      ReferencesOkamoto, Y., et al. 2007. Int. Heart J. 48, 369.
      Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314, 1008.
      Shiraga, M., et al. 2002. Cancer Res. 62, 5967.
      Mori, T., et al. 2001. Exp. Biol. Med. 226, 429.
      Yamada, A., et al. 2000. Inflamm. Res. 49, 144.
      Product Information
      CAS number223472-31-9
      FormOff-white solid
      Hill FormulaC₂₂H₂₈N₂O₆
      Chemical formulaC₂₂H₂₈N₂O₆
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MMP Inhibitor V - CAS 223472-31-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MMP Inhibitor V - CAS 223472-31-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      444290

      References

      Reference overview
      Okamoto, Y., et al. 2007. Int. Heart J. 48, 369.
      Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314, 1008.
      Shiraga, M., et al. 2002. Cancer Res. 62, 5967.
      Mori, T., et al. 2001. Exp. Biol. Med. 226, 429.
      Yamada, A., et al. 2000. Inflamm. Res. 49, 144.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-April-2009 RFH
      Synonyms(2S,4S)-N-Hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide, ONO-4817
      DescriptionAn orally active non-peptidyl hydroxamate compound that acts as an effective broad-spectrum inhibitor against MMP-2/3/8/9/12/13 (Ki = 0.73, 42, 1.1, 2.1, 0.45, and 1.1 nM, respectively), but not MMP-1 (IC50 = 1.6 µM), MMP-7 (Ki = 2.5 µM), or other serine proteases (no activity against chymotrypsin or plasmin at 100 µM). Widely used in studying MMP-mediated diseases development in vivo. Also reported to block P-LAP secretase activity (≥70% inhibition of P-LAP shedding at 10 µM) that is otherwise not inhibited by TIMP-1/2 in CHO cell cultures in vitro.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number223472-31-9
      Chemical formulaC₂₂H₂₈N₂O₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (30 mg/ml) or Ethanol (15 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesOkamoto, Y., et al. 2007. Int. Heart J. 48, 369.
      Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314, 1008.
      Shiraga, M., et al. 2002. Cancer Res. 62, 5967.
      Mori, T., et al. 2001. Exp. Biol. Med. 226, 429.
      Yamada, A., et al. 2000. Inflamm. Res. 49, 144.