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444294 MMP-2 Inhibitor IV - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₃H₁₄ClNO₈P₂S

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444294-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable, bisphosphonate derivative that displays nanomolar activity against MMP-2 (IC50 = 37 nM), with good selectivity over MMP-8 (320 nM), MMP-9 (> 1 µM), and MMP-14 (> 1 µM). It is shown to inhibit osteoclast activity in a macrophage cell line, J774 (IC50 = 1.7 µM), which is more potent compared with other bisphosphonates such as Alendronate (Cat. No. 126855), (IC50 = 30 µM), and Zolendronate (7.8 µM), without observable cytotoxicity in HepG2 cells. At 25 µM, it abolishes the formation of actin rings, which are functional structures that are typical of resorbing osteoclasts, at activity levels comparable with those of zolendronic acid, inhibits bone resportion in vitro, and demonstrates cytotoxic properties in murine osteoclasts.
      Catalogue Number444294
      Brand Family Calbiochem®
      Synonyms(4'-chlorobiphenyl-4-ylsulfonamido)methylenediphosphonic acid, Bone Resorption Inhibitor
      References
      ReferencesRubino, M.T., et al. 2011. Chem. Med. Chem. 6, 1258.
      Product Information
      FormOff-white powder
      Hill FormulaC₁₃H₁₄ClNO₈P₂S
      Chemical formulaC₁₃H₁₄ClNO₈P₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MMP-2 Inhibitor IV - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MMP-2 Inhibitor IV - Calbiochem Certificates of Analysis

      TitleLot Number
      444294

      References

      Reference overview
      Rubino, M.T., et al. 2011. Chem. Med. Chem. 6, 1258.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-July-2012 JSW
      Synonyms(4'-chlorobiphenyl-4-ylsulfonamido)methylenediphosphonic acid, Bone Resorption Inhibitor
      DescriptionA cell-permeable, bisphosphonate derivative that displays nanomolar activity against MMP-2 (IC50 = 37 nM), with good selectivity over MMP-8 (320 nM), MMP-9 (> 1 µM), and MMP-14 (> 1 µM). It is shown to inhibit osteoclast activity in a macrophage cell line, J774 (IC50 = 1.7 µM), which is more potent compared with other bisphosphonates such as Alendronate (Cat. No. 126855), (IC50 = 30 µM), and Zolendronate (7.8 µM), without observable cytotoxicity in HepG2 cells. At 25 µM, it abolishes the formation of actin rings, which are functional structures that are typical of resorbing osteoclasts, at activity levels comparable with those of zolendronic acid, inhibits bone resportion in vitro, and demonstrates cytotoxic properties in murine osteoclasts.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₃H₁₄ClNO₈P₂S
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mg/ml; clear, colorless solution)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesRubino, M.T., et al. 2011. Chem. Med. Chem. 6, 1258.