MABMAG-83K | MILLIPLEX MAP Mouse Amyloid Beta Magnetic Bead Panel - Multiplex Assay

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Overview

Replacement Information
Description
Catalogue NumberMABMAG-83K
Trade Name
  • MILLIPLEX
DescriptionMILLIPLEX MAP Mouse Amyloid Beta Magnetic Bead Panel - Multiplex Assay
OverviewThe MILLIPLEX® MAP Mouse Amyloid Beta Magnetic Bead Panel is to be used for the simultaneous quantification of Aβ40 and Aβ42. This kit may be used only for the analysis mouse serum, plasma, cerebrospinal fluid (CSF) and tissue culture samples. This is a configurable assay, and one or both analytes can be selected: amyloid β40, amyloid β42.

MILLIPLEX® MAP offers the broadest selection of analytes across a wide range of disease states and species. Once the analytes of interest have been identified, you can rely on the quality that we build into each kit to produce results you can trust. In addition to the assay characteristics listed in the protocol, other performance criteria evaluated during the validation process include: cross-reactivity, dilution linearity, kit stability and sample behavior (e.g. detectability and stability). Each panel and kit meets stringent manufacturing criteria to ensure batch-to-batch reproducibility.

Each MILLIPLEX® MAP panel and kit includes:
• Quality controls (QCs) provided to qualify assay performance

• Comparison of standard (calibrator) and QC lots to a reference lot to ensure lot-to-lot consistency

• Optimized serum matrix to mimic native analyte environment

• Detection antibody cocktails designed to yield consistent analyte profiles within panel


EMD Millipore’s MILLIPLEX® MAP Mouse Amyloid Beta Magnetic Bead Panel is part of the most versatile system available for your research. From our single to multiplex biomarker solutions, we partner with you to design, develop, analytically validate and build the most comprehensive library available for protein detection and quantitation.
Background InformationThe MILLIPLEX® MAP Mouse Amyloid Beta Magnetic Bead Panel enables you to evaluate and quantitate Aβ40 and Aβ42 in your mouse research models. Coupled with the Luminex xMAP® platform in a magnetic bead format, you receive the advantage of ideal speed and sensitivity, allowing quantitative multiplex detection of multiple analytes simultaneously, which can dramatically improve productivity.
References
Product Information
Components
  • Mouse ABeta Standard, 1 vial, lyophilized
  • Mouse ABeta Quality Control 1, 1 vial, lyophilized
  • Mouse ABeta Quality Control 2, 1 vial, lyophilized
  • Serum Matrix (0.08% Sodium Azide) 1 vial, lyophilized
  • Set of one 96-Well Plate with 2 sealers
  • Assay Buffer, 1 bottle, 30 mL
  • Wash Buffer, 10X (0.05% Proclin), 1 bottle, 60 mL
  • Mouse ABeta Detection Antibody, 1 bottle, 3.2 mL
  • Streptavidin-Phycoerythrin, 1 bottle, 3.2 mL
  • Mixing Bottle, 1 bottle
Detection methodLuminex xMAP
ConfigurationDesign your multiplex kit by choosing available analytes within this panel.
Precision, %
  • Inter-assay: < 10% CV
  • Intra-assay: < 5% CV
Panel TypeMAGNETIC Neuroscience
Applications
ApplicationThe MILLIPLEX® MAP Mouse Amyloid Beta Magnetic Bead Panel is a 2-plex kit containing all reagents needed for simultaneous quantification of Aβ40 and Aβ42 in mouse serum, plasma, CSF and tissue culture samples.
Key Applications
  • Multiplexing
Application NotesEMD Millipore’s MILLIPLEX® MAP Mouse Amyloid Beta Magnetic Bead Panel is a 2-plex kit used for the simultaneous quantification of any or all of the following analytes in mouse serum, plasma, cerebrospinal fluid (CSF), and tissue culture samples: Amyloid beta 1-40 (Aβ40), Amyloid beta 1-42 (Aβ42).
• An overnight (16-18 hours) incubation at 2-8°C is recommended.
• This assay requires 25 μL of 1:2 dilution of serum or plasma, a 1:10 dilution of cerebrospinal fluid (CSF) or neat/appropriately diluted tissue culture supernatant.
Biological Information
SpecificityThere was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel.
Species Reactivity
  • Mouse
Analytes Available
  • Amyloid β40
  • Amyloid β42
Assay PanelEverything you need in a single kit.
Cross ReactivityThere was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel.
Accuracy
  • Spike recovery for Aβ1-40 is 80%.
  • Spike recovery for Aβ1-42 is 88%.
Physicochemical Information
Sensitivity
  • Aβ1-40: 3.6 pg/mL (MinDC+2SD)
  • Aβ1-42: 4.8 pg/mL (MinDC+2SD)
Standard Curve Range
  • Aβ1-40: 3 - 2500 pg/mL
  • Aβ1-42: 7 - 5000 pg/mL
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsRecommended storage for kit components is 2 - 8°C.
Packaging Information
Material Size96-well plate
Material Package96-well plate
Transport Information
Supplemental Information
Specifications

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