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444145 MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem

The MDM2 Inhibitor, also referenced under CAS 562823-84-1, controls the biological activity of MDM2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: trans-4-Iodo, 4ʹ-boranyl-chalcone, MDM2 Antagonist IV

Primary Target: MDM2
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444145
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
562823-84-1C₁₅H₁₂BIO₃

Pricing & Availability

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444145-10MG
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      Description
      OverviewA cell-permeable boranyl-chalcone that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex. Exhibits selective toxicity towards MDM2 overexpressing human breast cancer cell lines (IC50 = 10, 8.8, and 7 µM for MDA-MB-435, MDA-MB-231, and Wt-MCF7, respectively) compared to normal breast cell lines (IC50 = 75 and 63 µM for MCF-10A and MCF-12A, respectively).
      Catalogue Number444145
      Brand Family Calbiochem®
      Synonymstrans-4-Iodo, 4ʹ-boranyl-chalcone, MDM2 Antagonist IV
      References
      ReferencesKumar, S.K., et al. 2003. J. Med. Chem. 46, 2813.
      Product Information
      CAS number562823-84-1
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₁₅H₁₂BIO₃
      Chemical formulaC₁₅H₁₂BIO₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMDM2
      Primary Target IC<sub>50</sub>10, 8.8, and 7 µM in selective toxicity for MDA-MB-435, MDA-MB-231, and Wt-MCF7, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Identification Number
      Catalog Number GTIN
      444145-10MG4055977205459

      Documentation

      MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      444145

      References

      Reference overview
      Kumar, S.K., et al. 2003. J. Med. Chem. 46, 2813.

      Brochure

      Title
      Interactive Pathway Calendar
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-February-2008 JSW
      Synonymstrans-4-Iodo, 4ʹ-boranyl-chalcone, MDM2 Antagonist IV
      DescriptionA cell-permeable boranyl-chalcone compound that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex formation. Exhibits selective toxicity to MDM2-overexpressing human breast cancer cell lines (IC50 = 10 µM for MDA-MB-435, 8.8 µM for MDA-MB-231, and 7 µM for Wt-MCF7) compared to normal breast cell lines (IC50 = 75 µM for MCF-10A and 63 µM for MCF-12A).
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number562823-84-1
      Chemical formulaC₁₅H₁₂BIO₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesKumar, S.K., et al. 2003. J. Med. Chem. 46, 2813.