Millipore Sigma Vibrant Logo

444143 MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₃₀H₃₀Cl₂N₄O₄ 548472-68-0

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
444143-1MG
Retrieving availability...
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Plastic ampoule 1 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewA cell-permeable cis-imidazoline compound that acts as a potent and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) and displays antitumor properties. Activates p53 pathway by binding MDM2 in the p53-binding pocket and inhibits MDM2-p53 interaction. Shown to suppress tumor growth by induction of apoptosis in several cancer cells with wild-type p53 and in xenografted tumor mice. A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444151) in DMSO is also available.
      Catalogue Number444143
      Brand Family Calbiochem®
      SynonymsMDM2 Inhibitor IV
      References
      ReferencesThompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
      Vassilev, L.T., et al. 2004. Science 303, 844.
      Product Information
      CAS number548472-68-0
      ATP CompetitiveN
      FormSolid
      Hill FormulaC₃₀H₃₀Cl₂N₄O₄
      Chemical formulaC₃₀H₃₀Cl₂N₄O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMDM2
      Primary Target IC<sub>50</sub>90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b
      Purity≥98% by TLC and HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      444143

      References

      Reference overview
      Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
      Vassilev, L.T., et al. 2004. Science 303, 844.

      Brochure

      Title
      Interactive Pathway Calendar
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-August-2008 RFH
      SynonymsMDM2 Inhibitor IV
      DescriptionA cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
      FormSolid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number548472-68-0
      Chemical formulaC₃₀H₃₀Cl₂N₄O₄
      Structure formulaStructure formula
      Purity≥98% by TLC and HPLC
      SolubilityDMSO (25 mg/ml) or Ethanol (25 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesThompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
      Vassilev, L.T., et al. 2004. Science 303, 844.