437650 Lipopolysaccharide, Salmonella typhimurium - Calbiochem

Overview

Replacement Information

Key Specifications Table

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437650-5MG
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      Plastic ampoule 5 mg
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      Description
      OverviewStimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.
      Catalogue Number437650
      Brand Family Calbiochem®
      References
      ReferencesHattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
      Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
      Norimatsu, M., et al. 1995. Infect. Immun. 63, 1122.
      Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
      Zhang, Y.H., et al. 1993. Infect. Immun. 61, 5044.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInducible nitric oxide synthase
      Physicochemical Information
      Cell permeableN
      Contaminantsprotein: ≤2%; nucleic acid: ≤2%
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSOJ0895637
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Lipopolysaccharide, Salmonella typhimurium - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Lipopolysaccharide, Salmonella typhimurium - Calbiochem Certificates of Analysis

      TitleLot Number
      437650

      References

      Reference overview
      Hattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
      Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
      Norimatsu, M., et al. 1995. Infect. Immun. 63, 1122.
      Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
      Zhang, Y.H., et al. 1993. Infect. Immun. 61, 5044.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-June-2013 JSW
      DescriptionEndotoxin lipopolysaccharides initiate a variety of biochemical cell activation pathways (PKC, cAMP-dependent protein kinase, arachidonate metabolism, protein myristoylation, and activation of G-proteins). These unique macromolecules have been extensively studied in order to elucidate and define revelent pathophysiological parameters of endotoxin shock, a profound life-threatening consequence of bacterial sepsis. More recently, these bacterial products have generated intense interest due to their pluripotential immunostimulatory activity, as manifested by the activation of host cells (e.g. B lymphocytes, macrophages) to functional differentiation. Host cells activated by lipopolysaccharides produce a spectrum of hormone-active lymphokines and monokines, including interferons (α, β, and γ), interleukins (IL-1 and IL-6), tumor necrosis factor, platelet activating factor and procoagulant tissue factor. Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.
      FormLyophilized
      RTECSOJ0895637
      Contaminantsprotein: ≤2%; nucleic acid: ≤2%
      SolubilityH₂O (5 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
      Toxicity Harmful
      ReferencesHattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
      Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
      Norimatsu, M., et al. 1995. Infect. Immun. 63, 1122.
      Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
      Zhang, Y.H., et al. 1993. Infect. Immun. 61, 5044.