531147 MilliporeLassomycin - Calbiochem
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Lassomycin - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Mycobacterium Bactericide II, Lassomycin, {cyclic(GLRRLFAD)}-QLVGRRNI-CO₂CH₃, ClpC1P1P2 Proteolytic Complex Inhibitor, ClpP1P2 Proteolytic Activity Inhibitor
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Overview
Replacement Information |
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Key Specifications Table
Empirical Formula |
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C₈₃H₁₄₂N₃₀O₂₀ |
Pricing & Availability
Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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5.31147.0001 |
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Glass bottle | 5 mg |
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Description | |
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Overview | A highly basic synthetic 16-aminoacid cyclic peptide that displays bactericidal activity against multiple species of growing and dormant mycobacteria, including drug-resistant Mycobacterium tuberculosis (MBC = 1- 4 µg/ml) in a time-dependent manner. Displays only a trivial activity against other bacteria (MIC > 50 µg/ml) and mammalian cells (IC50 = 350 µg/ml in NIH 3T3 and HepG2 cells). Acts by reversibly binding to a highly acidic N-terminal region of the ClpC1 ATPase complex (Kd = 410 nM) and stimulates its ATPase activity, but uncouples it from ClpP1P2-dependent proteolysis, a step that is essential for mycobacterium viability. Does not affect other related hexameric AAA ATPases. Displays greater bactericidal potency against M. tuberculosis than rifampicin (Cat. No. 557303). Please note that the molecular weight for this compound is batch-specific due to variable water content. |
Catalogue Number | 531147 |
Brand Family | Calbiochem® |
Synonyms | Mycobacterium Bactericide II, Lassomycin, {cyclic(GLRRLFAD)}-QLVGRRNI-CO₂CH₃, ClpC1P1P2 Proteolytic Complex Inhibitor, ClpP1P2 Proteolytic Activity Inhibitor |
References | |
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References | Gavrish, E., et al. 2014. Chem. Biol. 21, 509. |
Product Information | |
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Form | White powder |
Formulation | Supplied as a trifluoroacetate salt. |
Hill Formula | C₈₃H₁₄₂N₃₀O₂₀ |
Chemical formula | C₈₃H₁₄₂N₃₀O₂₀ |
Hygroscopic | Hygroscopic |
Reversible | Y |
Quality Level | MQ200 |
Applications |
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Biological Information | |
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Primary Target | ClpC1 ATPase complex |
Purity | ≥95% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Peptide Sequence | {cyclic(Gly-Leu-Arg-Arg-Leu-Phe-Ala-Asp)}-Gln-Leu-Val-Gly-Arg-Arg-Asn-Ile-CO₂CH₃ |
Dimensions |
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Materials Information |
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Toxicological Information |
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Safety Information according to GHS |
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Safety Information |
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Product Usage Statements |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Transport Information |
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Supplemental Information |
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Specifications |
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Documentation
Lassomycin - Calbiochem SDS
Title |
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References
Reference overview |
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Gavrish, E., et al. 2014. Chem. Biol. 21, 509. |
Brochure
Title |
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NPI Flyer- Epigenetics and Nuclear Function Feature (EMD) |
New Products - Antibodies, Small Molecule, Inhibitors |
Technical Info
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White Paper: Further considerations of antibody validation and usage. (EMD) |
Data Sheet | ||||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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