Product Information
Applications
Biological Information
Primary TargetmGlu₂ & mGlu₃
Primary Target K<sub>i</sub>149 nM and 92 nM for human mGlu₂ and mGlu₃, respectively.
Purity≥98% by NMR
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months ta -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

LY-404,039 - CAS 635318-55-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Seeman, P., 2013. Neuropharmacology. 66, 87.
Rorick-Kehn, L., et al. 2007. J. Pharmacol. Exp. Ther. 321, 308.
Fell, M., et al. 2008. J. Pharmacol. Exp. Ther. 326, 209.
Rodd, Z., et al. 2006. Behav. Brain Res. 171, 207.
Mezler, M., et al. 2010. Curr. Opi. In Investigational Drugs. 11, 833.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-July-2013 JSW
Synonyms(1R,4S,5S,6S)-4-[[(2S)-2-Amino-4-(methylthio)-1-oxobutyl]amino]-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
DescriptionA highly selective and potent agonist for recombinant human mGlu2 and mGlu3 receptors (Ki = 149 nM and 92 nM, respectively) and for rat neurons mGlu2/3 receptors (Ki = 88 nM). Negligible interactions with other mGlu receptors and ionotropic glutamate receptors, glutamate transporter subtypes, monoamine and other receptors. Widely used for investigating neuropsychiatric disorders in animal models and developing potential treatment for human mental disorders, such as schizophrenia.
FormWhite powder
CAS number635318-55-7
Chemical formulaC₇H₉NO₆S
Structure formulaStructure formula
Purity≥98% by NMR
SolubilityDMSO (0.25 mg/ml) or dilute NaOH (10 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months ta -20°C.
Toxicity Standard Handling
ReferencesSeeman, P., 2013. Neuropharmacology. 66, 87.
Rorick-Kehn, L., et al. 2007. J. Pharmacol. Exp. Ther. 321, 308.
Fell, M., et al. 2008. J. Pharmacol. Exp. Ther. 326, 209.
Rodd, Z., et al. 2006. Behav. Brain Res. 171, 207.
Mezler, M., et al. 2010. Curr. Opi. In Investigational Drugs. 11, 833.

Related Products & Applications

Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Agonists > Glutamate Receptor Agonists