489479 LSD1 Inhibitor IV, RN-1, 2HCl - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₃H₂₉N₃O₂ • 2HCl

Pricing & Availability

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489479-10MG
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      Description
      OverviewA cell-permeable tranylcypromine (parnate; Cat. No. 616431) analog that acts as a potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50 = 70 nM in a HRP-coupled assay using H3K4Me2 peptide substrate). Forms a covalent adduct with flavin adenine dinucleotide (FAD). Shown to cross the blood brain barrier. Exhibits moderate selectivity over amine oxidases MAO-A and MAO-B (IC50 = 0.51 and 2.785 µM, respectively). Displays desirable pharmacokinetic properties (brain/plasma exposure ratio of 88.9), and impairs long-term memory without affecting short-term memory in mice (10 mg/kg, i.p.).
      Catalogue Number489479
      Brand Family Calbiochem®
      SynonymsHistone Lysine Demethylase Inhibitor VI, MOA Inhibitor III, 2-(1R,2S)-2-(4-(Benzyloxy)phenyl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone, HCl, BHC110 Inhibitor IV, KDM1 Inhibitor IV, LSD Inhibitor IV
      References
      ReferencesNeelamegam, R., et al. 2011. ACS Chem. Neurosci. 3, 120.
      Product Information
      FormYellow solid
      Hill FormulaC₂₃H₂₉N₃O₂ • 2HCl
      Chemical formulaC₂₃H₂₉N₃O₂ • 2HCl
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      ApplicationLSD1 Inhibitor IV, RN-1, HCl, is a cell-permeable, potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50 = 70 nM).
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      LSD1 Inhibitor IV, RN-1, 2HCl - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      LSD1 Inhibitor IV, RN-1, 2HCl - Calbiochem Certificates of Analysis

      TitleLot Number
      489479

      References

      Reference overview
      Neelamegam, R., et al. 2011. ACS Chem. Neurosci. 3, 120.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-March-2016 MJ
      SynonymsHistone Lysine Demethylase Inhibitor VI, MOA Inhibitor III, 2-(1R,2S)-2-(4-(Benzyloxy)phenyl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone, HCl, BHC110 Inhibitor IV, KDM1 Inhibitor IV, LSD Inhibitor IV
      DescriptionA cell-permeable tranylcypromine (parnate; Cat. No. 616431) analog that acts as a potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50 = 70 nM in a HRP-coupled assay using H3K4Me2 peptide substrate). Forms a covalent adduct with flavin adenine dinucleotide (FAD). Shown to cross the blood brain barrier. Exhibits moderate selectivity over amine oxidases MAO-A and MAO-B (IC50 = 0.51 and 2.785 µM, respectively). Displays desirable pharmacokinetic properties (brain/plasma exposure ratio of 88.9), and impairs long-term memory without affecting short-term memory in mice (10 mg/kg, i.p.).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₃H₂₉N₃O₂ • 2HCl
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityH₂O (2.5 mg/ml) or DMSO (2.5 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesNeelamegam, R., et al. 2011. ACS Chem. Neurosci. 3, 120.