489479 Sigma-AldrichLSD1 Inhibitor IV, RN-1, 2HCl - Calbiochem
LSD1 Inhibitor IV, RN-1, HCl, is a cell-permeable, potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50 = 70 nM).
More>> LSD1 Inhibitor IV, RN-1, HCl, is a cell-permeable, potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50 = 70 nM). Less<<Synonyms: LSD Inhibitor IV, BHC110 Inhibitor IV, KDM1 Inhibitor IV, Histone Lysine Demethylase Inhibitor VI, MOA Inhibitor III, 2-(1R,2S)-2-(4-(Benzyloxy)phenyl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone, HCl
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Overview
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Key Specifications Table
Empirical Formula |
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C₂₃H₂₉N₃O₂ • 2HCl |
Pricing & Availability
Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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489479-10MG |
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Glass bottle | 10 mg |
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Description | |
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Overview | A cell-permeable tranylcypromine (parnate; Cat. No. 616431) analog that acts as a potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50 = 70 nM in a HRP-coupled assay using H3K4Me2 peptide substrate). Forms a covalent adduct with flavin adenine dinucleotide (FAD). Shown to cross the blood brain barrier. Exhibits moderate selectivity over amine oxidases MAO-A and MAO-B (IC50 = 0.51 and 2.785 µM, respectively). Displays desirable pharmacokinetic properties (brain/plasma exposure ratio of 88.9), and impairs long-term memory without affecting short-term memory in mice (10 mg/kg, i.p.). |
Catalogue Number | 489479 |
Brand Family | Calbiochem® |
Synonyms | LSD Inhibitor IV, BHC110 Inhibitor IV, KDM1 Inhibitor IV, Histone Lysine Demethylase Inhibitor VI, MOA Inhibitor III, 2-(1R,2S)-2-(4-(Benzyloxy)phenyl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone, HCl |
References | |
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References | Neelamegam, R., et al. 2011. ACS Chem. Neurosci. 3, 120. |
Product Information | |
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Form | Yellow solid |
Hill Formula | C₂₃H₂₉N₃O₂ • 2HCl |
Chemical formula | C₂₃H₂₉N₃O₂ • 2HCl |
Hygroscopic | Hygroscopic |
Structure formula Image | |
Quality Level | MQ200 |
Applications | |
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Application | LSD1 Inhibitor IV, RN-1, HCl, is a cell-permeable, potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50 = 70 nM). |
Biological Information | |
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Purity | ≥97% by HPLC |
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Packaged under inert gas | Packaged under inert gas |
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Specifications |
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Global Trade Item Number | |
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Catalog Number | GTIN |
489479-10MG | 04055977273403 |
Documentation
LSD1 Inhibitor IV, RN-1, 2HCl - Calbiochem SDS
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LSD1 Inhibitor IV, RN-1, 2HCl - Calbiochem Certificates of Analysis
Title | Lot Number |
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489479 |
References
Reference overview |
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Neelamegam, R., et al. 2011. ACS Chem. Neurosci. 3, 120. |